Longitudinal Retinal Changes in MOGAD

Objective Patients with myelin oligodendrocyte glycoprotein antibody (MOG‐IgG)‐associated disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro‐axonal loss, which can be quantified by optical coherence tomography (OCT). We assessed whether ON‐independent retinal atrophy can...

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Veröffentlicht in:	Annals of neurology 2022-09, Vol.92 (3), p.476-485
Hauptverfasser:	Oertel, Frederike Cosima, Sotirchos, Elias S., Zimmermann, Hanna G., Motamedi, Seyedamirhosein, Specovius, Svenja, Asseyer, Eva Susanna, Chien, Claudia, Cook, Lawrence, Vasileiou, Eleni, Filippatou, Angeliki, Calabresi, Peter A., Saidha, Shiv, Pandit, Lekha, D'Cunha, Anitha, Outteryck, Olivier, Zéphir, Hélène, Pittock, Sean, Flanagan, Eoin P., Bhatti, M. Tariq, Rommer, Paulus S., Bsteh, Gabriel, Zrzavy, Tobias, Kuempfel, Tania, Aktas, Orhan, Ringelstein, Marius, Albrecht, Philipp, Ayzenberg, Ilya, Pakeerathan, Thivya, Knier, Benjamin, Aly, Lilian, Asgari, Nasrin, Soelberg, Kerstin, Marignier, Romain, Tilikete, Caroline Froment, Cobo Calvo, Alvaro, Villoslada, Pablo, Sanchez‐Dalmau, Bernardo, Martinez‐Lapiscina, Elena H., Llufriu, Sara, Green, Ari J., Yeaman, Michael R., Smith, Terry J., Brandt, Alexander U., Chen, John, Paul, Friedemann, Havla, Joachim, Altintas, Ayse, Ashtari, Fereshte, Bichuetti, Denis, Castillo, Ibis Soto, Andrade, Mariana, Fontenelle, Huda, Saif, Hyun, Jae‐Won, Jacob, Anu, Kafieh, Rahele, Kim, Ho Jin, Leocani, Letizia, Mao‐Draayer, Yang, Leite, Marie Isabel, May, Eugene F., Palace, Jaqueline, Lana Peixoto, Marco Aurélio, Pisa, Marco, Radaelli, Marta, Rimler, Zoe, Roca‐Fernandez, Adriana, Senger, Thomas, Seze, Jérôme, Siritho, Sasitorn, Stiebel‐Kalish, Hadas, Tanriverdi, Uygur, Tavares, Ivan Maynart, Tongco, Caryl
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Atrophy Damage Data acquisition Edema Eye Glycoproteins Immunoglobulin G Myelin Nerves Neuritis Oligodendrocyte-myelin glycoprotein Optic nerve Optic neuritis Optical Coherence Tomography Retina Retinal degeneration Thinning
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Zusammenfassung:	Objective Patients with myelin oligodendrocyte glycoprotein antibody (MOG‐IgG)‐associated disease (MOGAD) suffer from severe optic neuritis (ON) leading to retinal neuro‐axonal loss, which can be quantified by optical coherence tomography (OCT). We assessed whether ON‐independent retinal atrophy can be detected in MOGAD. Methods Eighty patients with MOGAD and 139 healthy controls (HCs) were included. OCT data was acquired with (1) Spectralis spectral domain OCT (MOGAD: N = 66 and HCs: N = 103) and (2) Cirrus high‐definition OCT (MOGAD: N = 14 and HCs: N = 36). Macular combined ganglion cell and inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) were quantified. Results At baseline, GCIPL and pRNFL were lower in MOGAD eyes with a history of ON (MOGAD‐ON) compared with MOGAD eyes without a history of ON (MOGAD‐NON) and HCs (p
ISSN:	0364-5134 1531-8249
DOI:	10.1002/ana.26440