Feto‐maternal hemorrhage with placental chorioangioma: Two case reports

The infant was delivered via emergency cesarean section because of non-reassuring fetal status; a cardiotocogram showed the presence of severe variable deceleration and decreased variability. A histological examination revealed a small chorioangioma (10 × 10 × 4 mm; a capillary type) with Glut1-positive cells near the surface of the placenta and several chorionic stem vessels located near the periphery of the tumor (Fig. Table 1 Literature review of fetomaternal hemorrhage with chorioangiomas Our report Sims et al., 1976 5 Stiller et al., 1986 1 Santamaria et al., 1987 2 Brandt et al., 1989 3 Kawano et al., 2013 6 Case 1 2 3 4 5 6 7 Infants Sex Female Female Male Female Female Female Female Gestational age (weeks) 35 37 39 39 36 37 35 Birthweight (g) 2,596 2,418 2,200 3,070 2,425 2,340 1,840 Apgar score 1 min 7 5 Low 1 Low 1 5 Apgar score 5 min 8 5 Low 4 Low 4 5 Blood type B, Rh+ B, Rh+ A, Rh+ A, Rh+ NA NA NA Hemoglobin (g/dL) 9.9 4.0 8.4 7.5 NA 3.0 4.3 Outcome Alive Discharged on day 12 Alive Discharged on day 14 Alive Alive Died 6 h after birth NA Alive Discharged on day 57 Tumors Fetal ultrasound Detected Not detected NA NA NA NA NA Size (mm) 130 × 130 × 15 10 × 10 × 4 22 × 18 Maximum 50 Large 30 15 Location Margin of the placenta Near the chorionic stem vessels Near the insertion of umbilical vessels Multiple in the placenta NA NA Near the insertion of umbilical vessels Mothers Ages (years) 24 31 32 31 23 20 35 Blood type A, Rh+ B, Rh+ A, Rh+ O, Rh+ NA AB, Rh+ O Irregular antibody Negative Negative NA NA NA Negative Negative Hemoglobin F (%) 2.1 5.1 7.0 1.5 2.4 5.4 4.6 Placental weight (g) 700 520 3100 550 453 NA 450 NA, not available.