Predictive Value of Immune Cell Functional Assay for Non-Cytomegalovirus Infection in Lung Transplant Recipients: A Multicenter Prospective Observational Study

Immune cell functional assay (ImmuKnow®) is a non-invasive method that measures the state of cellular immunity in immunosuppressed patients. We studied the prognostic value of the assay for predicting non-cytomegalovirus (CMV) infections in lung transplant recipients. A multicenter prospective obser...

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Veröffentlicht in:	Archivos de bronconeumología (English ed.) 2021-11, Vol.57 (11), p.690-696
Hauptverfasser:	Monforte, Víctor, Ussetti, Piedad, Castejón, Raquel, Sintes, Helena, Pérez, Virginia Luz, Laporta, Rosalía, Sole, Amparo, Cifrián, José Manuel, Marcos, Pedro J, Redel, Javier, Arcos, Ibai Los, Berastegui, Cristina, Alonso, Rodrigo, Rosado, Silvia, Escriva, Juan, Iturbe, David, Ovalle, Juan Pablo, Vaquero, José Manuel, López-Meseguer, Manuel, Mendoza, Alberto, Gómez-Ollés, Susana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate Humans Immunocompromised Host Lung Lung Transplantation Transplant Recipients
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Zusammenfassung:	Immune cell functional assay (ImmuKnow®) is a non-invasive method that measures the state of cellular immunity in immunosuppressed patients. We studied the prognostic value of the assay for predicting non-cytomegalovirus (CMV) infections in lung transplant recipients. A multicenter prospective observational study of 92 patients followed up from 6 to 12 months after transplantation was performed. Immune cell functional assay was carried out at 6, 8, 10, and 12 months. Twenty-three patients (25%) developed 29 non-CMV infections between 6 and 12 months post-transplant. At 6 months, the immune response was moderate (ATP 225-525ng/mL) in 14 (15.2%) patients and low (ATP
ISSN:	1579-2129 1579-2129
DOI:	10.1016/j.arbr.2020.12.012