A novel 2-dimensional nanocomposite as a mediator for the determination of doxorubicin in biological samples
In our study, the electrochemical properties of a novel activated nanocomposite were studied with 2-dimensional graphitic carbon nitride/sodium dodecyl sulfate/graphene nanoplatelets on the screen-printed electrodes (2D-g-C3N4/SDS/GNPs/SPE). The as-fabricated sensor exhibited excellent electrochemic...
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| Veröffentlicht in: | Environmental research 2022-10, Vol.213, p.113590-113590, Article 113590 |
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| creator | Mehmandoust, Mohammad Khoshnavaz, Yasamin Karimi, Fatemeh Çakar, Soner Özacar, Mahmut Erk, Nevin |
| description | In our study, the electrochemical properties of a novel activated nanocomposite were studied with 2-dimensional graphitic carbon nitride/sodium dodecyl sulfate/graphene nanoplatelets on the screen-printed electrodes (2D-g-C3N4/SDS/GNPs/SPE). The as-fabricated sensor exhibited excellent electrochemical performance, including wide dynamic ranges from 0.03 to 1.0 and 1.0–13.5 μM with a low limit of detection (LOD) of 10.0 nM. The fabricated 2D-g-C3N4/SDS/GNPs/SPE electrode exhibited high sensitivity, stability, good reproducibility, reusability, and repeatability towards DOX sensing. It can be utilized in real samples, including human plasma and urine, with excellent correlations and coefficients of variation below 6.0%. Therefore, this study presents potential application values in sensing DOX with efficient performance. Finally, the accuracy was attested by comparison with high-performance liquid chromatography (HPLC) as the reference method, signalizing a good agreement.
[Display omitted]
•A novel design to fabricate a sensitive electrochemical sensor was proposed for future analytical applications.•Synergistic effect of 2D-C3N4 and graphene nanoplatelets for modification of electrode.•Nano-molar determination of doxorubicin in real samples. |
| doi_str_mv | 10.1016/j.envres.2022.113590 |
| format | Article |
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[Display omitted]
•A novel design to fabricate a sensitive electrochemical sensor was proposed for future analytical applications.•Synergistic effect of 2D-C3N4 and graphene nanoplatelets for modification of electrode.•Nano-molar determination of doxorubicin in real samples.</description><identifier>ISSN: 0013-9351</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/j.envres.2022.113590</identifier><identifier>PMID: 35690088</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Biological sample ; Doxorubicin monitoring ; Graphene nanoplatelets ; Graphitic carbon nitride</subject><ispartof>Environmental research, 2022-10, Vol.213, p.113590-113590, Article 113590</ispartof><rights>2022 Elsevier Inc.</rights><rights>Copyright © 2022. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c325t-a11a9c99fbbb350a20c654bbf940eb2891019e8b924fd2a29b70d4f8ee0d3e9d3</citedby><cites>FETCH-LOGICAL-c325t-a11a9c99fbbb350a20c654bbf940eb2891019e8b924fd2a29b70d4f8ee0d3e9d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.envres.2022.113590$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35690088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehmandoust, Mohammad</creatorcontrib><creatorcontrib>Khoshnavaz, Yasamin</creatorcontrib><creatorcontrib>Karimi, Fatemeh</creatorcontrib><creatorcontrib>Çakar, Soner</creatorcontrib><creatorcontrib>Özacar, Mahmut</creatorcontrib><creatorcontrib>Erk, Nevin</creatorcontrib><title>A novel 2-dimensional nanocomposite as a mediator for the determination of doxorubicin in biological samples</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>In our study, the electrochemical properties of a novel activated nanocomposite were studied with 2-dimensional graphitic carbon nitride/sodium dodecyl sulfate/graphene nanoplatelets on the screen-printed electrodes (2D-g-C3N4/SDS/GNPs/SPE). The as-fabricated sensor exhibited excellent electrochemical performance, including wide dynamic ranges from 0.03 to 1.0 and 1.0–13.5 μM with a low limit of detection (LOD) of 10.0 nM. The fabricated 2D-g-C3N4/SDS/GNPs/SPE electrode exhibited high sensitivity, stability, good reproducibility, reusability, and repeatability towards DOX sensing. It can be utilized in real samples, including human plasma and urine, with excellent correlations and coefficients of variation below 6.0%. Therefore, this study presents potential application values in sensing DOX with efficient performance. Finally, the accuracy was attested by comparison with high-performance liquid chromatography (HPLC) as the reference method, signalizing a good agreement.
[Display omitted]
•A novel design to fabricate a sensitive electrochemical sensor was proposed for future analytical applications.•Synergistic effect of 2D-C3N4 and graphene nanoplatelets for modification of electrode.•Nano-molar determination of doxorubicin in real samples.</description><subject>Biological sample</subject><subject>Doxorubicin monitoring</subject><subject>Graphene nanoplatelets</subject><subject>Graphitic carbon nitride</subject><issn>0013-9351</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LJDEQxYO46Oj6DRbJ0UuPlaTTdi6CiLsKgpfdc8ifajdDdzImPYP77TfS6lGooih4rx71I-QHgzUD1l1u1hj3GcuaA-drxoRUcEBWDFTXgJLikKwAmGiUkOyYnJSyqSuTAo7IsZCdAuj7FRlvaEx7HClvfJgwlpCiGWk0Mbk0bVMJM1JTqKET-mDmlOlQe_6L1OOMeQrRzNVD00B9ek15Z4MLkdayIY3pObh6rphpO2L5Tr4NZix49j5PyZ-fd79v75vHp18PtzePjRNczo1hzCin1GCtFRIMB9fJ1tpBtYCW96r-r7C3ireD54YrewW-HXpE8AKVF6fkYrm7zellh2XWUygOx9FETLuieXclO-ACZJW2i9TlVErGQW9zmEz-pxnoN856oxfO-o2zXjhX2_l7ws5WMJ-mD7BVcL0IsP65D5h1cQGjqxAzuln7FL5O-A-rg5I3</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Mehmandoust, Mohammad</creator><creator>Khoshnavaz, Yasamin</creator><creator>Karimi, Fatemeh</creator><creator>Çakar, Soner</creator><creator>Özacar, Mahmut</creator><creator>Erk, Nevin</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20221001</creationdate><title>A novel 2-dimensional nanocomposite as a mediator for the determination of doxorubicin in biological samples</title><author>Mehmandoust, Mohammad ; Khoshnavaz, Yasamin ; Karimi, Fatemeh ; Çakar, Soner ; Özacar, Mahmut ; Erk, Nevin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-a11a9c99fbbb350a20c654bbf940eb2891019e8b924fd2a29b70d4f8ee0d3e9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biological sample</topic><topic>Doxorubicin monitoring</topic><topic>Graphene nanoplatelets</topic><topic>Graphitic carbon nitride</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mehmandoust, Mohammad</creatorcontrib><creatorcontrib>Khoshnavaz, Yasamin</creatorcontrib><creatorcontrib>Karimi, Fatemeh</creatorcontrib><creatorcontrib>Çakar, Soner</creatorcontrib><creatorcontrib>Özacar, Mahmut</creatorcontrib><creatorcontrib>Erk, Nevin</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mehmandoust, Mohammad</au><au>Khoshnavaz, Yasamin</au><au>Karimi, Fatemeh</au><au>Çakar, Soner</au><au>Özacar, Mahmut</au><au>Erk, Nevin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel 2-dimensional nanocomposite as a mediator for the determination of doxorubicin in biological samples</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>2022-10-01</date><risdate>2022</risdate><volume>213</volume><spage>113590</spage><epage>113590</epage><pages>113590-113590</pages><artnum>113590</artnum><issn>0013-9351</issn><eissn>1096-0953</eissn><abstract>In our study, the electrochemical properties of a novel activated nanocomposite were studied with 2-dimensional graphitic carbon nitride/sodium dodecyl sulfate/graphene nanoplatelets on the screen-printed electrodes (2D-g-C3N4/SDS/GNPs/SPE). The as-fabricated sensor exhibited excellent electrochemical performance, including wide dynamic ranges from 0.03 to 1.0 and 1.0–13.5 μM with a low limit of detection (LOD) of 10.0 nM. The fabricated 2D-g-C3N4/SDS/GNPs/SPE electrode exhibited high sensitivity, stability, good reproducibility, reusability, and repeatability towards DOX sensing. It can be utilized in real samples, including human plasma and urine, with excellent correlations and coefficients of variation below 6.0%. Therefore, this study presents potential application values in sensing DOX with efficient performance. Finally, the accuracy was attested by comparison with high-performance liquid chromatography (HPLC) as the reference method, signalizing a good agreement.
[Display omitted]
•A novel design to fabricate a sensitive electrochemical sensor was proposed for future analytical applications.•Synergistic effect of 2D-C3N4 and graphene nanoplatelets for modification of electrode.•Nano-molar determination of doxorubicin in real samples.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>35690088</pmid><doi>10.1016/j.envres.2022.113590</doi><tpages>1</tpages></addata></record> |
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| ispartof | Environmental research, 2022-10, Vol.213, p.113590-113590, Article 113590 |
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| source | ScienceDirect Freedom Collection (Elsevier) |
| subjects | Biological sample Doxorubicin monitoring Graphene nanoplatelets Graphitic carbon nitride |
| title | A novel 2-dimensional nanocomposite as a mediator for the determination of doxorubicin in biological samples |
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