A novel 2-dimensional nanocomposite as a mediator for the determination of doxorubicin in biological samples

In our study, the electrochemical properties of a novel activated nanocomposite were studied with 2-dimensional graphitic carbon nitride/sodium dodecyl sulfate/graphene nanoplatelets on the screen-printed electrodes (2D-g-C3N4/SDS/GNPs/SPE). The as-fabricated sensor exhibited excellent electrochemical performance, including wide dynamic ranges from 0.03 to 1.0 and 1.0–13.5 μM with a low limit of detection (LOD) of 10.0 nM. The fabricated 2D-g-C3N4/SDS/GNPs/SPE electrode exhibited high sensitivity, stability, good reproducibility, reusability, and repeatability towards DOX sensing. It can be utilized in real samples, including human plasma and urine, with excellent correlations and coefficients of variation below 6.0%. Therefore, this study presents potential application values in sensing DOX with efficient performance. Finally, the accuracy was attested by comparison with high-performance liquid chromatography (HPLC) as the reference method, signalizing a good agreement. [Display omitted] •A novel design to fabricate a sensitive electrochemical sensor was proposed for future analytical applications.•Synergistic effect of 2D-C3N4 and graphene nanoplatelets for modification of electrode.•Nano-molar determination of doxorubicin in real samples.