Nickel/Photoredox-Catalyzed Enantioselective Reductive Cross-Coupling between Vinyl Bromides and Benzyl Chlorides

Nickel/Photoredox-Catalyzed Enantioselective Reductive Cross-Coupling between Vinyl Bromides and Benzyl Chlorides

A visible-light-promoted nickel/photoredox-catalyzed reductive cross-coupling reaction between vinyl bromides and benzyl chlorides is reported. A diverse array of enantioenriched allylic centers containing products could be achieved in good yields (up to 90%) and high enantioselectivities (up to 95%...

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Veröffentlicht in:Journal of organic chemistry 2022-06, Vol.87 (12), p.8048-8058
Hauptverfasser: Lu, Qianqian, Guan, Haixing, Wang, Yan-En, Xiong, Dan, Lin, Tingzhi, Xue, Fei, Mao, Jianyou
Format: Artikel
Sprache:eng
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Zusammenfassung:A visible-light-promoted nickel/photoredox-catalyzed reductive cross-coupling reaction between vinyl bromides and benzyl chlorides is reported. A diverse array of enantioenriched allylic centers containing products could be achieved in good yields (up to 90%) and high enantioselectivities (up to 95% ee). The mechanistic studies show that this reductive cross-coupling involves a radical pathway.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.2c00707