miR143-3p–Mediated NRG-1–Dependent Mitochondrial Dysfunction Contributes to Olanzapine Resistance in Refractory Schizophrenia

Olanzapine is an effective antipsychotic medication for treatment-resistant schizophrenia (TRS); however, the therapeutic effectiveness of olanzapine has been found to vary in individual patients. It is imperative to unravel its resistance mechanisms and find reliable targets to develop novel precis...

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Veröffentlicht in:	Biological psychiatry (1969) 2022-09, Vol.92 (5), p.419-433
Hauptverfasser:	Sun, Jing, Zhang, Xiaoya, Cong, Qijie, Chen, Dong, Yi, Zhenghui, Huang, Hailiang, Wang, Cong, Li, Mo, Zeng, Rongsen, Liu, Yunxi, Huai, Cong, Chen, Luan, Liu, Chuanxin, Zhang, Yan, Xu, Yong, Fan, Lingzi, Wang, Guoqiang, Song, Chuanfu, Wei, Muyun, Du, Huihui, Zhu, Jinhang, He, Lin, Qin, Shengying
Format:	Artikel
Sprache:	eng
Schlagworte:	miR143-3p Mitochondrial dysfunction Molecular mechanism of olanzapine resistance Neuregulin-1 NRG-1 TRS
Online-Zugang:	Volltext
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