miR143-3p–Mediated NRG-1–Dependent Mitochondrial Dysfunction Contributes to Olanzapine Resistance in Refractory Schizophrenia

miR143-3p–Mediated NRG-1–Dependent Mitochondrial Dysfunction Contributes to Olanzapine Resistance in Refractory Schizophrenia

Olanzapine is an effective antipsychotic medication for treatment-resistant schizophrenia (TRS); however, the therapeutic effectiveness of olanzapine has been found to vary in individual patients. It is imperative to unravel its resistance mechanisms and find reliable targets to develop novel precis...

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Veröffentlicht in:Biological psychiatry (1969) 2022-09, Vol.92 (5), p.419-433
Hauptverfasser: Sun, Jing, Zhang, Xiaoya, Cong, Qijie, Chen, Dong, Yi, Zhenghui, Huang, Hailiang, Wang, Cong, Li, Mo, Zeng, Rongsen, Liu, Yunxi, Huai, Cong, Chen, Luan, Liu, Chuanxin, Zhang, Yan, Xu, Yong, Fan, Lingzi, Wang, Guoqiang, Song, Chuanfu, Wei, Muyun, Du, Huihui, Zhu, Jinhang, He, Lin, Qin, Shengying
Format: Artikel
Sprache:eng
Schlagworte:
miR143-3p
Mitochondrial dysfunction
Molecular mechanism of olanzapine resistance
Neuregulin-1
NRG-1
TRS
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Zusammenfassung:Olanzapine is an effective antipsychotic medication for treatment-resistant schizophrenia (TRS); however, the therapeutic effectiveness of olanzapine has been found to vary in individual patients. It is imperative to unravel its resistance mechanisms and find reliable targets to develop novel precise therapeutic strategies. Unbiased RNA sequencing analysis was performed using homogeneous populations of neural stem cells derived from induced pluripotent stem cells in 3 olanzapine responder (reduction of Positive and Negative Syndrome Scale score ≥25%) and 4 nonresponder (reduction of Positive and Negative Syndrome Scale score
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2022.03.012