Hyperinsulinemia: beneficial or harmful or both on glucose homeostasis

Insulin, a principal anabolic hormone produced by pancreatic β-cells, has a primary function to storage nutrients following excessive energy intake. Pre- or early type 2 diabetes stages present a hyperinsulinemia (β-cell dysfunction) and insulin resistance. Initiation of hyperinsulinemia is triggere...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of physiology: endocrinology and metabolism 2022-07, Vol.323 (1), p.E2-E7
Hauptverfasser: Xing, JingJing, Chen, Chen
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Insulin, a principal anabolic hormone produced by pancreatic β-cells, has a primary function to storage nutrients following excessive energy intake. Pre- or early type 2 diabetes stages present a hyperinsulinemia (β-cell dysfunction) and insulin resistance. Initiation of hyperinsulinemia is triggered by a loss of first phase glucose-stimulated insulin secretion with altered membrane ion channel distribution. More factors, including insulin resistance and excessive proliferation of β-cells, deteriorate the hyperinsulinemia, whereas the hyperinsulinemia contributes to further development of insulin resistance and type 2 diabetes; to develop eventually late-stage diabetes with absolute insulin deficiency. In this mini review, the major focus was put on causes and pathophysiology of hyperinsulinemia, the metabolic consequences and current treatment of hyperinsulinemia were discussed. The data used in this narrative review were collected mainly from relevant discovery in last 3 years.
ISSN:0193-1849
1522-1555
DOI:10.1152/ajpendo.00441.2021