Standardization of risk prediction model reporting in cancer‐associated thrombosis: Communication from the ISTH SSC subcommittee on hemostasis and malignancy

Since the development of the Khorana score to predict risk of cancer‐associated venous thromboembolism (VTE), many modified and de novo risk prediction models (RPMs) have been proposed. Comparison of the prognostic performance across models requires comprehensive reporting and standardized methods for model development, validation and evaluation. To improve the standardization of RPM reporting, the Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD) tool was published in 2015. To better understand the quality of reporting and development of RPMs for cancer‐associated VTE, we performed a literature search of published RPMs and assessed each model using the TRIPOD checklist. Our results yielded 29 RPMs for which 30 items were evaluated. There was a non‐significant (p = 0.15) improvement in reporting of the 30 items in the post‐TRIPOD era (81%) versus the pre‐TRIPOD era (75%). Of seven items (title, sample size, missing data handling, baseline demographics, methods and results for model performance, and supplemental resources) with the lowest reporting in the pre‐TRIPOD era (