Mitochondrial dysfunction in cumulus cells is related to decreased reproductive capacity in advanced-age women

Mitochondrial dysfunction in cumulus cells is related to decreased reproductive capacity in advanced-age women

To reveal the relationship between mitochondrial function in cumulus cells (CCs) and the aging-related decline in ovarian function and reproductive capacity. Retrospective and transcriptome analysis of human tissue. University hospital. A total of 186 infertile women with normal weight and no other...

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Veröffentlicht in:Fertility and sterility 2022-08, Vol.118 (2), p.393-404
Hauptverfasser: Lu, Xinmei, Liu, Yubing, Xu, Jun, Cao, Xiang, Zhang, Doudou, Liu, Miao, Liu, Suying, Dong, Xi, Shi, Huijuan
Format: Artikel
Sprache:eng
Schlagworte:
Adenosine Triphosphate - metabolism
cumulus cells
Cumulus Cells - metabolism
diminished ovarian reserve
DNA, Mitochondrial - genetics
DNA, Mitochondrial - metabolism
Female
Humans
Infertility, Female - diagnosis
Infertility, Female - genetics
Infertility, Female - metabolism
mitochondria
Mitochondria - metabolism
Oocytes - metabolism
OXPHOS
Reproductive aging
Retrospective Studies
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Beschreibung
Zusammenfassung:To reveal the relationship between mitochondrial function in cumulus cells (CCs) and the aging-related decline in ovarian function and reproductive capacity. Retrospective and transcriptome analysis of human tissue. University hospital. A total of 186 infertile women with normal weight and no other diseases, including 86 young women (aged
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2022.04.019