Are we closer to providing better guidance for prescribing metformin and exercise to patients?

(3) assessed cardiorespiratory fitness (VO2max), indices of fasted insulin sensitivity (homeostatic model assessment of insulin resistance [HOMA-IR]), and several cardiovascular disease risk factors (i.e., blood pressure, triglycerides, etc.) in people with metabolic syndrome, before and after exercise training and in the presence or absence of habitual metformin use. Additionally, with overwhelming evidence that exercise benefits nearly every aspect of human health, health care providers are prescribing metformin while also strongly encouraging their patients to be physically active. Sources of inter-individual variability in the therapeutic response of blood glucose control to exercise in type 2 diabetes: going beyond exercise dose.