Neurotrophin-3 Enhances the Effectiveness of Cell Therapy in Chronic Spinal Cord Injuries

Neurotrophin-3 Enhances the Effectiveness of Cell Therapy in Chronic Spinal Cord Injuries

Neurotrophin-3 enhances the effectiveness of human olfactory ensheathing cells in improving hind limb mobility in rats with post-traumatic cysts of the spinal cord. Transplantation of olfactory ensheathing cells into spinal cord cysts reduced their size; neurotrophin-3 did not modulate this effect....

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Veröffentlicht in:Bulletin of experimental biology and medicine 2022-05, Vol.173 (1), p.114-118
Hauptverfasser: Stepanova, O. V., Voronova, A. D., Chadin, A. V., Fursa, G. A., Karsuntseva, E. K., Valikhov, M. P., Semkina, A. S., Reshetov, I. V., Chekhonin, V. P.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell therapy
Cell Transplantation
Cell- and Tissue-Based Therapy
Clinical trials
Cysts
Cysts - therapy
Experiments
Humans
Injuries
Internal Medicine
Laboratory Medicine
Medical research
Nerve Growth Factors - genetics
Nerve Regeneration
Nervous system
Neurosurgery
Neurotrophin 3
Olfactory Bulb
Olfactory ensheathing cells
Olfactory Mucosa
Pathology
Rats
Spinal Cord
Spinal cord injuries
Spinal Cord Injuries - therapy
Statistical analysis
Surgery
Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
Transplantation
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Beschreibung
Zusammenfassung:Neurotrophin-3 enhances the effectiveness of human olfactory ensheathing cells in improving hind limb mobility in rats with post-traumatic cysts of the spinal cord. Transplantation of olfactory ensheathing cells into spinal cord cysts reduced their size; neurotrophin-3 did not modulate this effect. Combined preparation of human olfactory ensheathing cells and neurotrophin- 3 can be used in neurosurgery for the treatment of patients with spinal cord injuries.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-022-05504-4