O -Methylation of carboxylic acids with streptozotocin

O -Methylation of carboxylic acids with streptozotocin

The clinically used DNA-alkylating drug streptozotocin (STZ) was investigated using a simple work-up as an -methylating agent to transform various carboxylic acids, sulfonic acids and phosphorous acids into corresponding methyl esters, and did so with yields of up to 97% in 4 h at room temperature....

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Veröffentlicht in:Organic & biomolecular chemistry 2022-07, Vol.20 (26), p.5230-5233
Hauptverfasser: Zeng, Li-Yan, Liu, Yang, Han, Jiakun, Chen, Jinhong, Liu, Shuwen, Xi, Baomin
Format: Artikel
Sprache:eng
Schlagworte:
Alkylation
Carboxylic acids
DNA methylation
Esters
Phosphorous acid
Room temperature
Streptozocin
Substrates
Temperature tolerance
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Zusammenfassung:The clinically used DNA-alkylating drug streptozotocin (STZ) was investigated using a simple work-up as an -methylating agent to transform various carboxylic acids, sulfonic acids and phosphorous acids into corresponding methyl esters, and did so with yields of up to 97% in 4 h at room temperature. Good substrate tolerance was observed, and benefited from the mild conditions and compatibility of the reaction with water.
ISSN:1477-0520
1477-0539
DOI:10.1039/d2ob00578f