A multicentre study of the risk factors associated with recurrence of central serous chorioretinopathy

Purpose To investigate potential clinical and multimodal imaging factors in central serous chorioretinopathy (CSC) recurrence. Methods The study was performed at nine Japanese medical institutions for patients who had experienced an active CSC episode. Demographic data and medical history were reviewed retrospectively. Significant differences in chronic manifestation, leakage site, leakage point number, leakage intensity, choroidal hyperpermeability, central retinal thickness (CRT) and subfoveal choroidal thickness were analysed between the recurrence and non‐recurrence groups. Results In total, 538 eyes (538 patients) diagnosed with CSC (402 men, 136 women; mean age: 53.4 ± 11.9 years) were enrolled. Among them, 253 eyes (47.0%) developed ≥1 recurrence (follow‐up: 15.9 ± 13.5 months, range 3–86 months). Univariate and multivariate analyses indicated that a history of corticosteroid use (odds ratio [OR], 5.52; 95% confidence interval [CI], 1.39–21.92; p = 0.015), bilateral disease (OR, 3.94; 95% CI, 1.47–10.6; p = 0.007), chronic manifestations (OR, 7.12; 95% CI, 2.93–17.28; p