Propargyl Chalcones’ Radical Annulation/Sulfonation Reaction: Efficient Synthesis of Benzo[b]oxepin-5(2H)‑one and Chromane Derivatives

A novel and facile methodology for the synthesis of sulfonated benzo­[b]­oxepinone and chromane derivatives was reported by the reaction of propargyl chalcones with arylsulfonyl chloride via radical cascade annulation/sulfonation under laboratory conditions. Readily available propargyl chalcones, commercialized arylsulfonyl chloride, and simple reaction conditions make this six­(seven)-membered oxygen-containing heterocycles’ synthetic strategy more attractive and with significant application values.