mRNA based vaccines provide broad protection against different SARS-CoV-2 variants of concern

In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron...

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Veröffentlicht in:	Emerging microbes & infections 2022-12, Vol.11 (1), p.1550-1553
Hauptverfasser:	Wang, Haomeng, Chen, Zhao, Wang, Zhenghua, Li, Jin, Yan, Zhihong, Yuan, Jinbo, Zhu, Airu, Chen, Lan, Liu, Ye, Hu, Chenlong, Zhu, Ali, Li, Guowei, Li, Yuehu, Deng, Jie, Ma, Liqiao, Sui, Xiuwen, Miao, Wei, Li, Junqiang, Zheng, Xiuyu, Piao, Jinhua, Yao, Yanfeng, Rao, Juhong, Shan, Chao, Yuan, Zhiming, Zhao, Jincun, Zhu, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Neutralizing Antibodies, Viral Beta BNT162 Vaccine Coronaviruses COVID-19 COVID-19 - prevention & control Humans Letter mRNA mRNA Vaccines Omicron RNA, Messenger - genetics SARS-CoV-2 - genetics vaccine Vaccines, Synthetic
Online-Zugang:	Volltext
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Zusammenfassung:	In order to overcome the pandemic of COVID-19, messenger RNA (mRNA)-based vaccine has been extensively researched as a rapid and versatile strategy. Herein, we described the immunogenicity of mRNA-based vaccines for Beta and the most recent Omicron variants. The homologous mRNA-Beta and mRNA-Omicron and heterologous Ad5-nCoV plus mRNA vaccine exhibited high-level cross-reactive neutralization for Beta, original, Delta, and Omicron variants. It indicated that the COVID-19 mRNA vaccines have great potential in the clinical use against different SARS-CoV-2 variants.
ISSN:	2222-1751 2222-1751
DOI:	10.1080/22221751.2022.2081616