Synthesis and Aggregation of Double Hydrophilic Diblock Glycopolymers via Aqueous SET-LRP

Synthesis and Aggregation of Double Hydrophilic Diblock Glycopolymers via Aqueous SET-LRP

A chemically unprotected mannose-containing acrylate (ManA) monomer was synthesized and polymerized by Cu(0)-mediated radical polymerization in water (SET-LRP). One-pot block copolymerization was achieved upon addition of a solution of N-isopropylacrylamide (NIPAm) or diethylene glycol ethyl ether a...

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Veröffentlicht in:ACS macro letters 2014-05, Vol.3 (5), p.491-495
Hauptverfasser: Zhang, Qiang, Wilson, Paul, Anastasaki, Athina, McHale, Ronan, Haddleton, David M
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Sprache:eng
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Zusammenfassung:A chemically unprotected mannose-containing acrylate (ManA) monomer was synthesized and polymerized by Cu(0)-mediated radical polymerization in water (SET-LRP). One-pot block copolymerization was achieved upon addition of a solution of N-isopropylacrylamide (NIPAm) or diethylene glycol ethyl ether acrylate (DEGEEA) forming thermoresponsive double hydrophilic diblock glycopolymers which revealed self-assembly properties in aqueous solution forming well-defined, sugar-decorated nanoparticles.
ISSN:2161-1653
2161-1653
DOI:10.1021/mz5001724