HE4 is associated with clinical risk prognostic factors and survival outcome in primary fallopian tube carcinoma patients

Aim To explore whether HE4 was associated with clinical risk prognostic factors and survival outcome in primary fallopian tube carcinoma patients. Methods Ninety‐six primary fallopian tube carcinoma (PFTC) patients from March 2011 to June 2019 were enrolled in this study. Serum CA125 and HE4 concentrations were measured at four time points including primary diagnosis, postsurgery, pre‐recurrence, and recurrence. The relations between clinical risk prognostic factors with HE4 concentrations were investigated, and multivariate survival analysis was used to calculate the hazard ratios between HE4 levels with recurrence‐free survival and overall survival. Results HE4 were significantly elevated in poor performance status, advanced stage, high histological grade and residual tumor diameter >1 cm, and positive lymph node status, respectively, compared with those in well performance status, early stage, low histological grade, residual tumor diameter ≤1 cm, and negative lymph node status, respectively. Multivariate survival analysis indicated serum HE4 can predict outcome of recurrence‐free survival and overall survival with hazard ratios of 9.92 (95% confidence interval [CI]: 2.95–33.32) and 3.12 (95% CI: 1.07–9.08), respectively. Conclusion HE4 is associated with clinical risk prognostic factors in PFTC and contributes to predict survival outcome in PFTC cases.