Role of mitochondria on UV-induced skin damage and molecular mechanisms of active chemical compounds targeting mitochondria

Mitochondria are the principal place of energy metabolism and ROS production, leading to mtDNA being especially sensitive to the impacts of oxidative stress. Our review aims to elucidate and update the mechanisms of mitochondria in UV-induced skin damage. The mitochondrial deteriorative response to UV manifests morphological and functional alterations, including mitochondrial fusion and fission, mitochondrial biogenesis, mitochondrial energy metabolism and mitophagy. Additionally, we conclude the effect and molecular mechanisms of active chemical components to protect skin from UV-induced damage via mitochondrial protection which have been described in the last five years, showing prospective prospects in cosmetics as new therapeutic targets. •Mitochondrial dysfunction and mitophagy have ascertained an indispensable function in skin homeostasis and dysfunctions.•The mechanisms of mitochondria in UV-induced skin damage have been elucidated and updated.•The molecular mechanisms of active chemical components to protect skin from UV-induced mitochondrial damage.•Mitochondria-targeted treatments show prospective prospects in cosmetics.