Analysis of the chemical composition of a bioceramic based on hydroxyapatite and tricalcium phosphate

Bioimplants, pellets and coatings for modern medical and dental procedures are prepared from bioceramics consisting of hydroxyapatite (over 95%) and tricalcium phosphate (to actively stimulate the growth of bone matter). Synthesis of orthophosphates is very complex due to hydrolysis and rate-depende...

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Veröffentlicht in:Powder metallurgy and metal ceramics 1998-03, Vol.37 (3-4), p.193-195
Hauptverfasser: Garbuz, V V, Dubok, V A, Kravchenko, L F, Kurochkin, V D, Ul'yanchich, N V, Kornilova, V I
Format: Artikel
Sprache:eng
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Zusammenfassung:Bioimplants, pellets and coatings for modern medical and dental procedures are prepared from bioceramics consisting of hydroxyapatite (over 95%) and tricalcium phosphate (to actively stimulate the growth of bone matter). Synthesis of orthophosphates is very complex due to hydrolysis and rate-dependent factors as well as avoidance of heavy metal impurities (As, Cd, Hg and Pb) which must be kept under 3, 5, 5, and 30 ppm respectively (per ASTM F-1185-88 and ASTM F-1088-87). As part of a development project to synthesize hydroxyapatite (HAP) and tricalcium phosphate (TCP) ceramics, improved and optimized analytical techniques have been devised to analyze compositions and impurities (detailed and discussed in this paper). The analytic error is 0.5% for Ca and 0.1% for P and heavy metal sensitivity is 0.4 ppm Cd, 1.4 ppm As, 5 ppm Hg and 0.2 ppm Pb, respectively. A modified internal standard technique was employed in which XRF intensities were normalized with respect to the intensity of the main component (Ca). Synthesized ceramics passed both the composition and impurity ASTM specifications (as detailed in this paper).
ISSN:1068-1302
1573-9066
DOI:10.1007/BF02675982