Serum leptin concentration is associated with the attainment of clinical outcomes in patients with axial spondyloarthritis treated with TNF inhibitors

To analyse the influence of adipokines on attaining the clinical outcomes in patients with axial spondyloarthritis (axSpA) treated with TNF inhibitors (TNFi), and then, to investigate the association of patients' characteristics and adipokine concentrations. This was a longitudinal study includ...

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Veröffentlicht in:	Clinical and experimental rheumatology 2023-03, Vol.41 (3), p.565-573
Hauptverfasser:	Hernández-Breijo, Borja, Novella-Navarro, Marta, Genre, Fernanda, Navarro-Compán, Victoria, Martínez-Feito, Ana, Remuzgo-Martínez, Sara, González-Gay, Miguel Ángel, Balsa, Alejandro, Plasencia-Rodríguez, Chamaida
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin Female Humans Leptin Longitudinal Studies Obesity Severity of Illness Index Spondylarthritis - drug therapy Spondylitis, Ankylosing - drug therapy Treatment Outcome Tumor Necrosis Factor Inhibitors - therapeutic use Tumor Necrosis Factor-alpha
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Beschreibung
Zusammenfassung:	To analyse the influence of adipokines on attaining the clinical outcomes in patients with axial spondyloarthritis (axSpA) treated with TNF inhibitors (TNFi), and then, to investigate the association of patients' characteristics and adipokine concentrations. This was a longitudinal study including 110 patients with axSpA who were initiated at TNFi and were followed-up for 6 months (m). Disease activity was assessed by Ankylosing Spondylitis Disease Activity Score (ASDAS) at baseline and at 6 m of treatment. Clinical outcomes at 6 m of treatment were defined as remission (ASDAS
ISSN:	0392-856X 1593-098X 1593-098X
DOI:	10.55563/clinexprheumatol/ou570o