Putting introns on retainer

Protein arginine methyltransferases (PRMTs) are overexpressed in many cancer types, including triple-negative breast cancer (TNBC). A new study shows that a reversible inhibitor of type I PRMTs suppresses TNBC tumor growth by inducing a viral mimicry response with retained introns.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature chemical biology 2022-08, Vol.18 (8), p.795-796
Hauptverfasser:	Srour, Nivine, Richard, Stéphane
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/1645/1792 631/67/1059 631/92/613 631/92/93 Antigens Apoptosis Biochemical Engineering Biochemistry Biology Bioorganic Chemistry Breast cancer Cancer therapies Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Cytokines DNA methylation Drugs Epigenetics Gene expression Immunology Immunotherapy Introns Lymphocytes Medical prognosis Metabolites Mimicry News & Views news-and-views Peptides Proteins Retention T cell receptors Tumors
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Beschreibung
Zusammenfassung:	Protein arginine methyltransferases (PRMTs) are overexpressed in many cancer types, including triple-negative breast cancer (TNBC). A new study shows that a reversible inhibitor of type I PRMTs suppresses TNBC tumor growth by inducing a viral mimicry response with retained introns.
ISSN:	1552-4450 1552-4469
DOI:	10.1038/s41589-022-01025-3