pH Stimuli‐Responsive, Rapidly Self‐healable Coatings Enhanced the Corrosion Resistance and Osteogenic Differentiation of Mg‐1Ca Osteoimplant

Mg‐Ca alloys have emerged as a promising research direction for biomedical implants in the orthopedic field. However, their clinical use is deterred by their fast corrosion rate. In this work, a pH stimuli‐responsive silk‐halloysite (HNT)/phytic acid (PA) self‐healing coating (Silk‐HNT/PA) is constructed to slow down the corrosion rate of Mg‐1Ca alloy and its cell viability and osteogenic differentiation ability are enhanced. The Silk‐HNT/PA coating exhibits appealing active corrosion protection, by eliciting pH‐triggerable self‐healing effects, while simultaneously affording superior biocompatibility and osteogenic differentiation ability. Moreover, in vivo studies by histological analysis also demonstrate better osseointegration for the Silk‐HNT/PA coated Mg‐1Ca alloy. In summary, the Silk‐HNT/PA coating in the present study has great potential in enhancing the biomedical utility of Mg alloys. A pH stimuli‐responsive silk‐halloysite (HNT)/phytic acid (PA) self‐healing coating (Silk‐HNT/PA) is fabricated on Mg‐1Ca alloy. Halloysite (HNT) significantly improves the loading efficiency and shortens the self‐healing time of Silk‐PA coating. The Silk‐HNT/PA coating improves the corrosion resistance and osteogenic differentiation of Mg‐1Ca alloy.