Pharmacodynamics, pharmacokinetics, safety, and tolerability of a ready‐to‐use, room temperature, liquid stable glucagon administered via an autoinjector pen to youth with type 1 diabetes

Pharmacodynamics, pharmacokinetics, safety, and tolerability of a ready‐to‐use, room temperature, liquid stable glucagon administered via an autoinjector pen to youth with type 1 diabetes

Background Prompt and reliable management of hypoglycemia in youth with diabetes is important to prevent serious medical complications. Objectives To determine efficacy, pharmacodynamics (PD), pharmacokinetics (PK), safety, and tolerability of a ready‐to‐use, liquid stable glucagon formulation admin...

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Veröffentlicht in:Pediatric diabetes 2022-09, Vol.23 (6), p.754-762
Hauptverfasser: Buckingham, Bruce, Sherr, Jennifer, Prestrelski, Steven J., Conoscenti, Valentina
Format: Artikel
Sprache:eng
Schlagworte:
Age
Diabetes
Diabetes mellitus (insulin dependent)
Dosage
Glucagon
Glucose
Hypoglycemia
Insulin
Nausea
pediatric
Pharmacodynamics
Pharmacokinetics
Plasma
Vomiting
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Zusammenfassung:Background Prompt and reliable management of hypoglycemia in youth with diabetes is important to prevent serious medical complications. Objectives To determine efficacy, pharmacodynamics (PD), pharmacokinetics (PK), safety, and tolerability of a ready‐to‐use, liquid stable glucagon formulation administered subcutaneously via an autoinjector pen to youth with type 1 diabetes (T1D). Methods After plasma glucose concentration was
ISSN:1399-543X
1399-5448
DOI:10.1111/pedi.13360