Human papillomavirus genotype distribution of genital keratotic lesions

Genital keratotic lesions include bowenoid papulosis (BP), which histologically resembles squamous cell carcinoma in situ containing high‐risk HPV, condyloma acuminatum (CA) that is a genital wart containing mostly low‐risk HPV, and genital seborrheic keratosis (GSK), which is a benign epidermal tum...

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Veröffentlicht in:Australasian journal of dermatology 2022-08, Vol.63 (3), p.e238-e243
Hauptverfasser: Seong, Seol Hwa, Jeong, Sun Mun, Jung, Jang Hwan, Kwon, Do Ik, Jang, Ji Yun, Kim, Joon Hee, Park, Jong Bin, Baek, Jae Woo, Suh, Kee Suck, Jang, Min Soo
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Sprache:eng
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Zusammenfassung:Genital keratotic lesions include bowenoid papulosis (BP), which histologically resembles squamous cell carcinoma in situ containing high‐risk HPV, condyloma acuminatum (CA) that is a genital wart containing mostly low‐risk HPV, and genital seborrheic keratosis (GSK), which is a benign epidermal tumour lacking a clear etiologic relationship with HPV. This study compared HPV genotype distributions among BP, CA and GSK and revealed that BP and GSK were related to high‐risk HPV whereas CA was related to low‐risk HPV. It is plausible that GSK is a distinct epidermal tumour often related to high‐risk HPV rather than merely a senescent form of CA considering the overall discrepancy in the frequency distribution of HPV genotypes along with histopathological differences, and the detection of high‐risk HPV in GSK alerts physicians to consider more active treatment and continued follow‐ups.
ISSN:0004-8380
1440-0960
DOI:10.1111/ajd.13867