Maternal thyroid disease in pregnancy and timing of pubertal development in sons and daughters

To study whether maternal thyroid disease in pregnancy is associated with pubertal timing in sons and daughters. Cohort study. National birth cohort and health registers. A total of 15,763 mothers and children from the Danish National Birth Cohort and its Puberty Cohort. Register-based and self-repo...

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Veröffentlicht in:Fertility and sterility 2022-07, Vol.118 (1), p.136-146
Hauptverfasser: Lunddorf, Lea L.H., Ernst, Andreas, Brix, Nis, Arendt, Linn H., Andersen, Stine L., Olsen, Jørn, Ramlau-Hansen, Cecilia H.
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Sprache:eng
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Zusammenfassung:To study whether maternal thyroid disease in pregnancy is associated with pubertal timing in sons and daughters. Cohort study. National birth cohort and health registers. A total of 15,763 mothers and children from the Danish National Birth Cohort and its Puberty Cohort. Register-based and self-reported information on maternal thyroid diseases during pregnancy (hyperthyroidism, hypothyroidism, benign goiter, or no thyroid disease [reference group]). The adjusted mean age difference (months) at attaining several self-reported pubertal milestones collected every 6 months using an interval-censored regression and the average difference in age at attaining all pubertal milestones using the Huber-White robust variance estimation (primary outcome). Sons of mothers with hyperthyroidism had earlier pubertal development (average difference, −2.9 [95% confidence interval (CI), −5.0 to −0.7] months) than unexposed sons. Maternal hypothyroidism was not associated with pubertal development in sons (average difference, −1.2 [95% CI, −5.1 to 2.7] months). We observed nonstatistically significant indications of earlier pubertal development in sons of mothers with benign goiter (average difference, −1.9 [95% CI, −4.6 to 0.9] months). Maternal thyroid disease was not associated with pubertal development in daughters (average difference (months), hyperthyroidism, −0.8 [95% CI, −2.8 to 1.2]; hypothyroidism, 0.3 [95% CI, −3.1 to 3.8]; and benign goiter, 0.7 [95% CI, −2.0 to 3.4]). We found indications of earlier pubertal development in sons of mothers with hyperthyroidism. More research is needed to further investigate the observed sex-specific association. Enfermedad tiroidea materna en embarazo y momento del desarrollo puberal en hijos e hijas. Estudiar si la enfermedad tiroidea materna en el embarazo está asociada con el momento de pubertad en hijos e hijas. Estudio de Cohorte. Un total de 15,763 madres e hijos del Cohorte Nacional Danés de Nacimiento y su Cohorte de Pubertad. Información autoreportada y basada en registros sobre enfermedad tiroidea materna durante el embarazo (hipertiroidismo, hipotiroidismo, bocio benigno, o sin enfermedad tiroidea [grupo de referencia]). La diferencia de la edad media ajustada (meses) al alcanzar varios hitos puberales autoreportados recopilados cada 6 meses usando una regresión censurada por intervalo y la diferencia promedio en la edad al alcanzar todos los hitos puberales usando la estimación de varianza robusta de Huber-White (result
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2022.03.018