Novel Schiff base scaffolds derived from 4‐aminoantipyrine and 2‐hydroxy‐3‐methoxy‐5‐(phenyldiazenyl)benzaldehyde: Synthesis, antibacterial, antioxidant and anti‐inflammatory

The synthesis of four new azo‐Schiff base ligands from 2‐hydroxy‐3‐methoxy‐5‐(phenyldiazenyl)benzaldehyde and 4‐aminoantipyrine is described in this study. The molecular structures of all the scaffolds were confirmed using NMR spectroscopies such as 1H and 13C, as well as FT‐IR and Mass spectroscopy. After successful synthesis and characterization of all the ligands, their in vitro antibacterial, antioxidant and anti‐inflammatory activities were carried out by using standard protocols. Results revealed that all the four ligands (L1‐L4) possessed excellent biological potency. Present work includes synthesis of four novel azo Schiff base ligands derived from 4‐aminoantipyrine and 2‐hydroxy‐3‐methoxy‐5‐(phenyldiazenyl)benzaldehyde. The molecular structures of all the scaffolds were confirmed by 1H and 13C NMR spectroscopy, FT‐IR spectroscopy and Mass spectroscopy. After successful synthesis and characterization of all the ligands, their In‐vitro antibacterial, antioxidant and antiinflammatory activities were carried out by using standard protocols. Results revealed that all the four ligands (L1‐L4) possessed good antimicrobial activity.