The Cerebrospinal Fluid Proteomic Response to Traumatic and Nontraumatic Acute Brain Injury: A Prospective Study
Background Quantitative analysis of ventricular cerebrospinal fluid (vCSF) proteins following acute brain injury (ABI) may help identify pathophysiological pathways and potential biomarkers that can predict unfavorable outcome. Methods In this prospective proteomic analysis study, consecutive patien...
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| Veröffentlicht in: | Neurocritical care 2022-10, Vol.37 (2), p.463-470 |
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| description | Background
Quantitative analysis of ventricular cerebrospinal fluid (vCSF) proteins following acute brain injury (ABI) may help identify pathophysiological pathways and potential biomarkers that can predict unfavorable outcome.
Methods
In this prospective proteomic analysis study, consecutive patients with severe ABI expected to require intraventricular catheterization for intracranial pressure (ICP) monitoring for at least 5 days and patients without ABI admitted for elective clipping of an unruptured cerebral aneurysm were included. vCSF samples were collected within the first 24 h after ABI and ventriculostomy insertion and then every 24 h for 5 days. In patients without ABI, a single vCSF sample was collected at the time of elective clipping. Data-independent acquisition and sequential window acquisition of all theoretical spectra (SWATH) mass spectrometry were used to compare differences in protein expression in patients with ABI and patients without ABI and in patients with traumatic and nontraumatic ABI. Differences in protein expression according to different ICP values, intensive care unit outcome, subarachnoid hemorrhage (SAH) versus traumatic brain injury (TBI), and good versus poor 3-month functional status (assessed by using the Glasgow Outcome Scale) were also evaluated. vCSF proteins with significant differences between groups were compared by using linear models and selected for gene ontology analysis using R Language and the Panther database.
Results
We included 50 patients with ABI (SAH
n
= 23, TBI
n
= 15, intracranial hemorrhage
n
= 6, ischemic stroke
n
= 3, others
n
= 3) and 12 patients without ABI. There were significant differences in the expression of 255 proteins between patients with and without ABI (
p
|
| doi_str_mv | 10.1007/s12028-022-01507-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2661088232</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2661088232</sourcerecordid><originalsourceid>FETCH-LOGICAL-c419t-ad86ac24689eae8f5fdc7f27718ae4c8bef54904a08e7e3c538e24cfaae98a2c3</originalsourceid><addsrcrecordid>eNp9kUlvFDEQRi1ERBb4AxyQJS5cmnhpb9yGEQmRIkAwnC2Puxp61N1uvCDNv8fDhETKgZOt8quv5HoIvaTkLSVEXSbKCNMNYawhVBDV0CfojAohG2IkfXq4t7SRhvNTdJ7SjhCmjBLP0CkXgnFD5RlaNj8BryHCNoa0DLMb8dVYhg5_iSFDmAaPv0JawpwA54A30ZXJ5Vp1c4c_hTnfF1a-ZMDvoxtmfDPvSty_w6tDTFrA5-E34G-5dPvn6KR3Y4IXd-cF-n71YbP-2Nx-vr5Zr24b31KTG9dp6TxrpTbgQPei77zqmVJUO2i93kIvWkNaRzQo4F5wDaz1vXNgtGOeX6A3x9wlhl8FUrbTkDyMo5shlGSZlJRozTir6OtH6C6UWFdRKVNXrJQ0tFLsSPn6pRSht0scJhf3lhJ78GGPPmz1Yf_6sIemV3fRZTtBd9_yT0AF-BFI9Wn-AfFh9n9i_wD-vJbI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2920277691</pqid></control><display><type>article</type><title>The Cerebrospinal Fluid Proteomic Response to Traumatic and Nontraumatic Acute Brain Injury: A Prospective Study</title><source>ProQuest Central (Alumni Edition)</source><source>ProQuest Central UK/Ireland</source><source>SpringerLink Journals - AutoHoldings</source><source>ProQuest Central</source><creator>Santacruz, Carlos A. ; Vincent, Jean-Louis ; Duitama, Jorge ; Bautista, Edwin ; Imbault, Virginie ; Bruneau, Michaël ; Creteur, Jacques ; Brimioulle, Serge ; Communi, David ; Taccone, Fabio S.</creator><creatorcontrib>Santacruz, Carlos A. ; Vincent, Jean-Louis ; Duitama, Jorge ; Bautista, Edwin ; Imbault, Virginie ; Bruneau, Michaël ; Creteur, Jacques ; Brimioulle, Serge ; Communi, David ; Taccone, Fabio S.</creatorcontrib><description>Background
Quantitative analysis of ventricular cerebrospinal fluid (vCSF) proteins following acute brain injury (ABI) may help identify pathophysiological pathways and potential biomarkers that can predict unfavorable outcome.
Methods
In this prospective proteomic analysis study, consecutive patients with severe ABI expected to require intraventricular catheterization for intracranial pressure (ICP) monitoring for at least 5 days and patients without ABI admitted for elective clipping of an unruptured cerebral aneurysm were included. vCSF samples were collected within the first 24 h after ABI and ventriculostomy insertion and then every 24 h for 5 days. In patients without ABI, a single vCSF sample was collected at the time of elective clipping. Data-independent acquisition and sequential window acquisition of all theoretical spectra (SWATH) mass spectrometry were used to compare differences in protein expression in patients with ABI and patients without ABI and in patients with traumatic and nontraumatic ABI. Differences in protein expression according to different ICP values, intensive care unit outcome, subarachnoid hemorrhage (SAH) versus traumatic brain injury (TBI), and good versus poor 3-month functional status (assessed by using the Glasgow Outcome Scale) were also evaluated. vCSF proteins with significant differences between groups were compared by using linear models and selected for gene ontology analysis using R Language and the Panther database.
Results
We included 50 patients with ABI (SAH
n
= 23, TBI
n
= 15, intracranial hemorrhage
n
= 6, ischemic stroke
n
= 3, others
n
= 3) and 12 patients without ABI. There were significant differences in the expression of 255 proteins between patients with and without ABI (
p
< 0.01). There were intraday and interday differences in expression of seven proteins related to increased inflammation, apoptosis, oxidative stress, and cellular response to hypoxia and injury. Among these, glial fibrillary acidic protein expression was higher in patients with ABI with severe intracranial hypertension (ICH) (ICP ≥ 30 mm Hg) or death compared to those without (log 2 fold change: + 2.4;
p
< 0.001), suggesting extensive primary astroglial injury or death. There were differences in the expression of 96 proteins between patients with traumatic and nontraumatic ABI (
p
< 0.05); intraday and interday differences were observed for six proteins related to structural damage, complement activation, and cholesterol metabolism. Thirty-nine vCSF proteins were associated with an increased risk of severe ICH (ICP ≥ 30 mm Hg) in patients with traumatic compared with nontraumatic ABI (
p
< 0.05). No significant differences were found in protein expression between patients with SAH versus TBI or between those with good versus poor 3-month Glasgow Outcome Scale score.
Conclusions
Dysregulated vCSF protein expression after ABI may be associated with an increased risk of severe ICH and death.</description><identifier>ISSN: 1541-6933</identifier><identifier>EISSN: 1556-0961</identifier><identifier>DOI: 10.1007/s12028-022-01507-1</identifier><identifier>PMID: 35523916</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aneurysms ; Biomarkers ; Catheters ; Cerebrospinal fluid ; Critical Care Medicine ; Intensive ; Intensive care ; Internal Medicine ; Ischemia ; Mass spectrometry ; Medicine ; Medicine & Public Health ; Metabolism ; Neurology ; Neurosurgery ; Original Work ; Patients ; Peptides ; Protein expression ; Proteins ; Scientific imaging ; Signal transduction ; Statistical analysis ; Traumatic brain injury</subject><ispartof>Neurocritical care, 2022-10, Vol.37 (2), p.463-470</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society 2022</rights><rights>2022. Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society.</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature and Neurocritical Care Society 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-ad86ac24689eae8f5fdc7f27718ae4c8bef54904a08e7e3c538e24cfaae98a2c3</citedby><cites>FETCH-LOGICAL-c419t-ad86ac24689eae8f5fdc7f27718ae4c8bef54904a08e7e3c538e24cfaae98a2c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12028-022-01507-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2920277691?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,21386,21387,27922,27923,33528,33529,33742,33743,41486,42555,43657,43803,51317,64383,64385,64387,72239</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35523916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santacruz, Carlos A.</creatorcontrib><creatorcontrib>Vincent, Jean-Louis</creatorcontrib><creatorcontrib>Duitama, Jorge</creatorcontrib><creatorcontrib>Bautista, Edwin</creatorcontrib><creatorcontrib>Imbault, Virginie</creatorcontrib><creatorcontrib>Bruneau, Michaël</creatorcontrib><creatorcontrib>Creteur, Jacques</creatorcontrib><creatorcontrib>Brimioulle, Serge</creatorcontrib><creatorcontrib>Communi, David</creatorcontrib><creatorcontrib>Taccone, Fabio S.</creatorcontrib><title>The Cerebrospinal Fluid Proteomic Response to Traumatic and Nontraumatic Acute Brain Injury: A Prospective Study</title><title>Neurocritical care</title><addtitle>Neurocrit Care</addtitle><addtitle>Neurocrit Care</addtitle><description>Background
Quantitative analysis of ventricular cerebrospinal fluid (vCSF) proteins following acute brain injury (ABI) may help identify pathophysiological pathways and potential biomarkers that can predict unfavorable outcome.
Methods
In this prospective proteomic analysis study, consecutive patients with severe ABI expected to require intraventricular catheterization for intracranial pressure (ICP) monitoring for at least 5 days and patients without ABI admitted for elective clipping of an unruptured cerebral aneurysm were included. vCSF samples were collected within the first 24 h after ABI and ventriculostomy insertion and then every 24 h for 5 days. In patients without ABI, a single vCSF sample was collected at the time of elective clipping. Data-independent acquisition and sequential window acquisition of all theoretical spectra (SWATH) mass spectrometry were used to compare differences in protein expression in patients with ABI and patients without ABI and in patients with traumatic and nontraumatic ABI. Differences in protein expression according to different ICP values, intensive care unit outcome, subarachnoid hemorrhage (SAH) versus traumatic brain injury (TBI), and good versus poor 3-month functional status (assessed by using the Glasgow Outcome Scale) were also evaluated. vCSF proteins with significant differences between groups were compared by using linear models and selected for gene ontology analysis using R Language and the Panther database.
Results
We included 50 patients with ABI (SAH
n
= 23, TBI
n
= 15, intracranial hemorrhage
n
= 6, ischemic stroke
n
= 3, others
n
= 3) and 12 patients without ABI. There were significant differences in the expression of 255 proteins between patients with and without ABI (
p
< 0.01). There were intraday and interday differences in expression of seven proteins related to increased inflammation, apoptosis, oxidative stress, and cellular response to hypoxia and injury. Among these, glial fibrillary acidic protein expression was higher in patients with ABI with severe intracranial hypertension (ICH) (ICP ≥ 30 mm Hg) or death compared to those without (log 2 fold change: + 2.4;
p
< 0.001), suggesting extensive primary astroglial injury or death. There were differences in the expression of 96 proteins between patients with traumatic and nontraumatic ABI (
p
< 0.05); intraday and interday differences were observed for six proteins related to structural damage, complement activation, and cholesterol metabolism. Thirty-nine vCSF proteins were associated with an increased risk of severe ICH (ICP ≥ 30 mm Hg) in patients with traumatic compared with nontraumatic ABI (
p
< 0.05). No significant differences were found in protein expression between patients with SAH versus TBI or between those with good versus poor 3-month Glasgow Outcome Scale score.
Conclusions
Dysregulated vCSF protein expression after ABI may be associated with an increased risk of severe ICH and death.</description><subject>Aneurysms</subject><subject>Biomarkers</subject><subject>Catheters</subject><subject>Cerebrospinal fluid</subject><subject>Critical Care Medicine</subject><subject>Intensive</subject><subject>Intensive care</subject><subject>Internal Medicine</subject><subject>Ischemia</subject><subject>Mass spectrometry</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Original Work</subject><subject>Patients</subject><subject>Peptides</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Scientific imaging</subject><subject>Signal transduction</subject><subject>Statistical analysis</subject><subject>Traumatic brain injury</subject><issn>1541-6933</issn><issn>1556-0961</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUlvFDEQRi1ERBb4AxyQJS5cmnhpb9yGEQmRIkAwnC2Puxp61N1uvCDNv8fDhETKgZOt8quv5HoIvaTkLSVEXSbKCNMNYawhVBDV0CfojAohG2IkfXq4t7SRhvNTdJ7SjhCmjBLP0CkXgnFD5RlaNj8BryHCNoa0DLMb8dVYhg5_iSFDmAaPv0JawpwA54A30ZXJ5Vp1c4c_hTnfF1a-ZMDvoxtmfDPvSty_w6tDTFrA5-E34G-5dPvn6KR3Y4IXd-cF-n71YbP-2Nx-vr5Zr24b31KTG9dp6TxrpTbgQPei77zqmVJUO2i93kIvWkNaRzQo4F5wDaz1vXNgtGOeX6A3x9wlhl8FUrbTkDyMo5shlGSZlJRozTir6OtH6C6UWFdRKVNXrJQ0tFLsSPn6pRSht0scJhf3lhJ78GGPPmz1Yf_6sIemV3fRZTtBd9_yT0AF-BFI9Wn-AfFh9n9i_wD-vJbI</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Santacruz, Carlos A.</creator><creator>Vincent, Jean-Louis</creator><creator>Duitama, Jorge</creator><creator>Bautista, Edwin</creator><creator>Imbault, Virginie</creator><creator>Bruneau, Michaël</creator><creator>Creteur, Jacques</creator><creator>Brimioulle, Serge</creator><creator>Communi, David</creator><creator>Taccone, Fabio S.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20221001</creationdate><title>The Cerebrospinal Fluid Proteomic Response to Traumatic and Nontraumatic Acute Brain Injury: A Prospective Study</title><author>Santacruz, Carlos A. ; Vincent, Jean-Louis ; Duitama, Jorge ; Bautista, Edwin ; Imbault, Virginie ; Bruneau, Michaël ; Creteur, Jacques ; Brimioulle, Serge ; Communi, David ; Taccone, Fabio S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-ad86ac24689eae8f5fdc7f27718ae4c8bef54904a08e7e3c538e24cfaae98a2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aneurysms</topic><topic>Biomarkers</topic><topic>Catheters</topic><topic>Cerebrospinal fluid</topic><topic>Critical Care Medicine</topic><topic>Intensive</topic><topic>Intensive care</topic><topic>Internal Medicine</topic><topic>Ischemia</topic><topic>Mass spectrometry</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Neurology</topic><topic>Neurosurgery</topic><topic>Original Work</topic><topic>Patients</topic><topic>Peptides</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Scientific imaging</topic><topic>Signal transduction</topic><topic>Statistical analysis</topic><topic>Traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santacruz, Carlos A.</creatorcontrib><creatorcontrib>Vincent, Jean-Louis</creatorcontrib><creatorcontrib>Duitama, Jorge</creatorcontrib><creatorcontrib>Bautista, Edwin</creatorcontrib><creatorcontrib>Imbault, Virginie</creatorcontrib><creatorcontrib>Bruneau, Michaël</creatorcontrib><creatorcontrib>Creteur, Jacques</creatorcontrib><creatorcontrib>Brimioulle, Serge</creatorcontrib><creatorcontrib>Communi, David</creatorcontrib><creatorcontrib>Taccone, Fabio S.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Neurocritical care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santacruz, Carlos A.</au><au>Vincent, Jean-Louis</au><au>Duitama, Jorge</au><au>Bautista, Edwin</au><au>Imbault, Virginie</au><au>Bruneau, Michaël</au><au>Creteur, Jacques</au><au>Brimioulle, Serge</au><au>Communi, David</au><au>Taccone, Fabio S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Cerebrospinal Fluid Proteomic Response to Traumatic and Nontraumatic Acute Brain Injury: A Prospective Study</atitle><jtitle>Neurocritical care</jtitle><stitle>Neurocrit Care</stitle><addtitle>Neurocrit Care</addtitle><date>2022-10-01</date><risdate>2022</risdate><volume>37</volume><issue>2</issue><spage>463</spage><epage>470</epage><pages>463-470</pages><issn>1541-6933</issn><eissn>1556-0961</eissn><abstract>Background
Quantitative analysis of ventricular cerebrospinal fluid (vCSF) proteins following acute brain injury (ABI) may help identify pathophysiological pathways and potential biomarkers that can predict unfavorable outcome.
Methods
In this prospective proteomic analysis study, consecutive patients with severe ABI expected to require intraventricular catheterization for intracranial pressure (ICP) monitoring for at least 5 days and patients without ABI admitted for elective clipping of an unruptured cerebral aneurysm were included. vCSF samples were collected within the first 24 h after ABI and ventriculostomy insertion and then every 24 h for 5 days. In patients without ABI, a single vCSF sample was collected at the time of elective clipping. Data-independent acquisition and sequential window acquisition of all theoretical spectra (SWATH) mass spectrometry were used to compare differences in protein expression in patients with ABI and patients without ABI and in patients with traumatic and nontraumatic ABI. Differences in protein expression according to different ICP values, intensive care unit outcome, subarachnoid hemorrhage (SAH) versus traumatic brain injury (TBI), and good versus poor 3-month functional status (assessed by using the Glasgow Outcome Scale) were also evaluated. vCSF proteins with significant differences between groups were compared by using linear models and selected for gene ontology analysis using R Language and the Panther database.
Results
We included 50 patients with ABI (SAH
n
= 23, TBI
n
= 15, intracranial hemorrhage
n
= 6, ischemic stroke
n
= 3, others
n
= 3) and 12 patients without ABI. There were significant differences in the expression of 255 proteins between patients with and without ABI (
p
< 0.01). There were intraday and interday differences in expression of seven proteins related to increased inflammation, apoptosis, oxidative stress, and cellular response to hypoxia and injury. Among these, glial fibrillary acidic protein expression was higher in patients with ABI with severe intracranial hypertension (ICH) (ICP ≥ 30 mm Hg) or death compared to those without (log 2 fold change: + 2.4;
p
< 0.001), suggesting extensive primary astroglial injury or death. There were differences in the expression of 96 proteins between patients with traumatic and nontraumatic ABI (
p
< 0.05); intraday and interday differences were observed for six proteins related to structural damage, complement activation, and cholesterol metabolism. Thirty-nine vCSF proteins were associated with an increased risk of severe ICH (ICP ≥ 30 mm Hg) in patients with traumatic compared with nontraumatic ABI (
p
< 0.05). No significant differences were found in protein expression between patients with SAH versus TBI or between those with good versus poor 3-month Glasgow Outcome Scale score.
Conclusions
Dysregulated vCSF protein expression after ABI may be associated with an increased risk of severe ICH and death.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>35523916</pmid><doi>10.1007/s12028-022-01507-1</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1541-6933 |
| ispartof | Neurocritical care, 2022-10, Vol.37 (2), p.463-470 |
| issn | 1541-6933 1556-0961 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2661088232 |
| source | ProQuest Central (Alumni Edition); ProQuest Central UK/Ireland; SpringerLink Journals - AutoHoldings; ProQuest Central |
| subjects | Aneurysms Biomarkers Catheters Cerebrospinal fluid Critical Care Medicine Intensive Intensive care Internal Medicine Ischemia Mass spectrometry Medicine Medicine & Public Health Metabolism Neurology Neurosurgery Original Work Patients Peptides Protein expression Proteins Scientific imaging Signal transduction Statistical analysis Traumatic brain injury |
| title | The Cerebrospinal Fluid Proteomic Response to Traumatic and Nontraumatic Acute Brain Injury: A Prospective Study |
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