Effects of acetazolamide on pulmonary artery pressure and prevention of high-altitude pulmonary edema after rapid active ascent to 4,559 m

Effects of acetazolamide on pulmonary artery pressure and prevention of high-altitude pulmonary edema after rapid active ascent to 4,559 m

Acetazolamide prevents acute mountain sickness (AMS) by inhibition of carbonic anhydrase. Since it also reduces acute hypoxic pulmonary vasoconstriction (HPV), it may also prevent high-altitude pulmonary edema (HAPE) by lowering pulmonary artery pressure. We tested this hypothesis in a randomized, p...

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Veröffentlicht in:Journal of applied physiology (1985) 2022-06, Vol.132 (6), p.1361-1369
Hauptverfasser: Berger, Marc Moritz, Sareban, Mahdi, Schiefer, Lisa Maria, Swenson, Kai E, Treff, Franziska, Schäfer, Larissa, Schmidt, Peter, Schimke, Magdalena M, Paar, Michael, Niebauer, Josef, Cogo, Annalisa, Kriemler, Susi, Schwery, Stefan, Pickerodt, Philipp A, Mayer, Benjamin, Bärtsch, Peter, Swenson, Erik R
Format: Artikel
Sprache:eng
Schlagworte:
Acetazolamide
Altitude
Ascent
Carbonic anhydrase
Carbonic anhydrases
Dexamethasone
Echocardiography
Edema
Heart
High altitude
High-altitude environments
Hypoxia
Mountains
Nifedipine
Oxygenation
Placebos
Pressure
Prevention
Pulmonary arteries
Pulmonary artery
Radiography
Statistical analysis
Vasoconstriction
Veins & arteries
Ventricle
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Zusammenfassung:Acetazolamide prevents acute mountain sickness (AMS) by inhibition of carbonic anhydrase. Since it also reduces acute hypoxic pulmonary vasoconstriction (HPV), it may also prevent high-altitude pulmonary edema (HAPE) by lowering pulmonary artery pressure. We tested this hypothesis in a randomized, placebo-controlled, double-blind study. Thirteen healthy, nonacclimatized lowlanders with a history of HAPE ascended (
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.00806.2021