Organometallic hotspot engineering for ultrasensitive EC-SERS detection of pathogenic bacteria-derived DNAs

Organometallic hotspot engineering for ultrasensitive EC-SERS detection of pathogenic bacteria-derived DNAs

The sensitivity and limit-of-detection (LOD) of the traditional surface-enhanced Raman spectroscopy (SERS) platform suffer from the requirement of precise positioning of small analytes, including DNAs and bacteria, into narrow hotspots. In this study, a novel SERS sensor was developed using electroc...

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Veröffentlicht in:Biosensors & bioelectronics 2022-08, Vol.210, p.114325-114325, Article 114325
Hauptverfasser: Lee, Soo Hyun, Lee, Won-Chul, Koh, Eun Hye, Ansah, Iris Baffour, Yang, Jun-Yeong, Mun, ChaeWon, Lee, Seunghun, Kim, Dong-Ho, Jung, Ho Sang, Park, Sung-Gyu
Format: Artikel
Sprache:eng
Schlagworte:
DNA scale Hotspot
Electrochemical surface-enhanced Raman spectroscopy
In situ deposition
Pathogenic bacteria
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Beschreibung
Zusammenfassung:The sensitivity and limit-of-detection (LOD) of the traditional surface-enhanced Raman spectroscopy (SERS) platform suffer from the requirement of precise positioning of small analytes, including DNAs and bacteria, into narrow hotspots. In this study, a novel SERS sensor was developed using electrochemical deposition onto metal nanopillars (ECOMPs) combined with complementary DNAs (cDNAs) for the detection of pathogenic bacteria. Applying a redox potential to AuCl4− ions actively engineered the organometallic hotspots based on the cDNAs in a short time (
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2022.114325