Inflammation‐related immune proteins in maternal plasma as potential predictive biomarkers for rescue cerclage outcome in women with cervical insufficiency

Problem This study aimed to determine whether various novel plasma mediators of immune regulation associated with inflammation could independently predict the clinical outcome of rescue cerclage in patients with cervical insufficiency (CI). Method of study A total of 41 singleton pregnant women (17–25 weeks) who underwent rescue cerclage for CI were retrospectively evaluated. Stored plasma samples were assayed for IGFBP‐1, ‐2, ‐3, IL‐6, latexin, LBP, lipocalin‐2, M‐CSF, MIP‐1α, MMP‐8, ‐9, pentraxin 3, resistin, S100A8, S100A8/A9, thrombospondin‐2, TIMP‐1, and TNFR2 levels. The primary outcome measures were spontaneous preterm birth (SPTB) at