ACTH(6-9)-Pro-Gly-Pro ameliorates anxiety-like and depressive-like behaviour and gut mucosal microbiota composition in rats under conditions of chronic restraint stress
The effects of the peptide ACTH(6–9)-Pro-Gly-Pro at doses of 5; 50; 500 μg/kg on the Wistar rats' behaviour and gut mucosal microbiota composition under conditions of chronic immobilization stress (CRS) were studied. CRS increased anxiety-like and depressive-like behaviour, disturbances in loco...
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| Veröffentlicht in: | Neuropeptides (Edinburgh) 2022-06, Vol.93, p.102247-102247, Article 102247 |
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| creator | Vorvul, Anton O. Bobyntsev, Igor I. Medvedeva, Olga A. Mukhina, Alexandra Y. Svishcheva, Maria V. Azarova, Iuliia E. Andreeva, Lyudmila A. Myasoedov, Nikolay F. |
| description | The effects of the peptide ACTH(6–9)-Pro-Gly-Pro at doses of 5; 50; 500 μg/kg on the Wistar rats' behaviour and gut mucosal microbiota composition under conditions of chronic immobilization stress (CRS) were studied. CRS increased anxiety-like and depressive-like behaviour, disturbances in locomotor activity and gut dysbiosis. Administration of ACTH(6–9)-Pro-Gly-Pro showed many phenotypic results. Peptide demonstrated anti-depressant activity at doses of 5 and 500 μg/kg by a decrease in the total immobile time in the FST. ACTH(6–9)-Pro-Gly-Pro administered at a dose of 50 μg/kg resulted in an anxiolytic effect which is shown by an increase in the time in the open arms of EPM (p |
| doi_str_mv | 10.1016/j.npep.2022.102247 |
| format | Article |
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CRS increased anxiety-like and depressive-like behaviour, disturbances in locomotor activity and gut dysbiosis. Administration of ACTH(6–9)-Pro-Gly-Pro showed many phenotypic results. Peptide demonstrated anti-depressant activity at doses of 5 and 500 μg/kg by a decrease in the total immobile time in the FST. ACTH(6–9)-Pro-Gly-Pro administered at a dose of 50 μg/kg resulted in an anxiolytic effect which is shown by an increase in the time in the open arms of EPM (p < 0.05) and a decrease in the time in the closed arms (p < 0.05). Moreover, the peptide led to a decrease in alpha- and beta-diversity of the gut microbiota (p < 0.01). Correlation and linear regression analysis demonstrated central mechanisms of ACTH(6–9)-Pro-Gly-Pro anxiolytic activity and both central and peripheral ones in an anti-depressant effect. In this way, peptide ACTH(6–9)-Pro-Gly-Pro could prevent the development of behavioural disturbances and gut dysbiosis caused by chronic restraint stress.</description><identifier>ISSN: 0143-4179</identifier><identifier>EISSN: 1532-2785</identifier><identifier>DOI: 10.1016/j.npep.2022.102247</identifier><identifier>PMID: 35487169</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>ACTH(6–9)-Pro-Gly-Pro ; Adrenocorticotropic hormone ; Adrenocorticotropic Hormone - pharmacology ; Animals ; Anxiety ; Anxiety - drug therapy ; Anxiety-like behaviour ; Behavior, Animal ; Chronic restraint stress ; Depressive-like behaviour ; Dysbacteriosis ; Dysbiosis ; Gastrointestinal Microbiome ; Gut microbiota ; Gut-brain axis ; Immobilization ; Intestinal microflora ; Locomotor activity ; Microbiota ; Mucosa ; Oligopeptides ; Peptides ; Proline - analogs & derivatives ; Rats ; Rats, Wistar</subject><ispartof>Neuropeptides (Edinburgh), 2022-06, Vol.93, p.102247-102247, Article 102247</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Jun 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-75ed9b637a5eebd3d8b705e1eece4e314f53bd8f30d7f0ce3e73f0bd6caca4f3</citedby><cites>FETCH-LOGICAL-c384t-75ed9b637a5eebd3d8b705e1eece4e314f53bd8f30d7f0ce3e73f0bd6caca4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0143417922000221$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35487169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vorvul, Anton O.</creatorcontrib><creatorcontrib>Bobyntsev, Igor I.</creatorcontrib><creatorcontrib>Medvedeva, Olga A.</creatorcontrib><creatorcontrib>Mukhina, Alexandra Y.</creatorcontrib><creatorcontrib>Svishcheva, Maria V.</creatorcontrib><creatorcontrib>Azarova, Iuliia E.</creatorcontrib><creatorcontrib>Andreeva, Lyudmila A.</creatorcontrib><creatorcontrib>Myasoedov, Nikolay F.</creatorcontrib><title>ACTH(6-9)-Pro-Gly-Pro ameliorates anxiety-like and depressive-like behaviour and gut mucosal microbiota composition in rats under conditions of chronic restraint stress</title><title>Neuropeptides (Edinburgh)</title><addtitle>Neuropeptides</addtitle><description>The effects of the peptide ACTH(6–9)-Pro-Gly-Pro at doses of 5; 50; 500 μg/kg on the Wistar rats' behaviour and gut mucosal microbiota composition under conditions of chronic immobilization stress (CRS) were studied. CRS increased anxiety-like and depressive-like behaviour, disturbances in locomotor activity and gut dysbiosis. Administration of ACTH(6–9)-Pro-Gly-Pro showed many phenotypic results. Peptide demonstrated anti-depressant activity at doses of 5 and 500 μg/kg by a decrease in the total immobile time in the FST. ACTH(6–9)-Pro-Gly-Pro administered at a dose of 50 μg/kg resulted in an anxiolytic effect which is shown by an increase in the time in the open arms of EPM (p < 0.05) and a decrease in the time in the closed arms (p < 0.05). Moreover, the peptide led to a decrease in alpha- and beta-diversity of the gut microbiota (p < 0.01). Correlation and linear regression analysis demonstrated central mechanisms of ACTH(6–9)-Pro-Gly-Pro anxiolytic activity and both central and peripheral ones in an anti-depressant effect. In this way, peptide ACTH(6–9)-Pro-Gly-Pro could prevent the development of behavioural disturbances and gut dysbiosis caused by chronic restraint stress.</description><subject>ACTH(6–9)-Pro-Gly-Pro</subject><subject>Adrenocorticotropic hormone</subject><subject>Adrenocorticotropic Hormone - pharmacology</subject><subject>Animals</subject><subject>Anxiety</subject><subject>Anxiety - drug therapy</subject><subject>Anxiety-like behaviour</subject><subject>Behavior, Animal</subject><subject>Chronic restraint stress</subject><subject>Depressive-like behaviour</subject><subject>Dysbacteriosis</subject><subject>Dysbiosis</subject><subject>Gastrointestinal Microbiome</subject><subject>Gut microbiota</subject><subject>Gut-brain axis</subject><subject>Immobilization</subject><subject>Intestinal microflora</subject><subject>Locomotor activity</subject><subject>Microbiota</subject><subject>Mucosa</subject><subject>Oligopeptides</subject><subject>Peptides</subject><subject>Proline - analogs & derivatives</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0143-4179</issn><issn>1532-2785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctuFDEQRS0EIkPgB1ggS2zCogc_-yGxiUaQIEWCxewtt11NPHTbje0eMX_EZ-JJBxYsWJVcdXyrdC9CrynZUkLr94etn2HeMsJYaTAmmidoQyVnFWta-RRtCBW8ErTpLtCLlA6EEMHa9jm64FK0Da27Dfp1vdvfXtVV9676GkN1M57OFesJRheizpCw9j8d5FM1uu9QHhZbmCOk5I6w9nq410cXlvgw_bZkPC0mJD3iyZkYeheyxiZMc0guu-Cx87hIJ7x4C7FMvH3oJxwGbO5j8M7gsiFH7XzGpZZtL9GzQY8JXj3WS7T_9HG_u63uvtx83l3fVYa3IleNBNv1NW-0BOgtt23fEAkUwIAATsUgeW_bgRPbDMQAh4YPpLe10UaLgV-iq1V2juHHUm5Qk0sGxlF7CEtSrJYt40zQrqBv_0EPxQNfjitU2xV_qSSFYitVnEgpwqDm6CYdT4oSdY5RHdQ5RnWOUa0xlk9vHqWXfgL798uf3ArwYQWgWHF0EFUyDrwB6yKYrGxw_9P_DVEosl8</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Vorvul, Anton O.</creator><creator>Bobyntsev, Igor I.</creator><creator>Medvedeva, Olga A.</creator><creator>Mukhina, Alexandra Y.</creator><creator>Svishcheva, Maria V.</creator><creator>Azarova, Iuliia E.</creator><creator>Andreeva, Lyudmila A.</creator><creator>Myasoedov, Nikolay F.</creator><general>Elsevier Ltd</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202206</creationdate><title>ACTH(6-9)-Pro-Gly-Pro ameliorates anxiety-like and depressive-like behaviour and gut mucosal microbiota composition in rats under conditions of chronic restraint stress</title><author>Vorvul, Anton O. ; Bobyntsev, Igor I. ; Medvedeva, Olga A. ; Mukhina, Alexandra Y. ; Svishcheva, Maria V. ; Azarova, Iuliia E. ; Andreeva, Lyudmila A. ; Myasoedov, Nikolay F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-75ed9b637a5eebd3d8b705e1eece4e314f53bd8f30d7f0ce3e73f0bd6caca4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>ACTH(6–9)-Pro-Gly-Pro</topic><topic>Adrenocorticotropic hormone</topic><topic>Adrenocorticotropic Hormone - pharmacology</topic><topic>Animals</topic><topic>Anxiety</topic><topic>Anxiety - drug therapy</topic><topic>Anxiety-like behaviour</topic><topic>Behavior, Animal</topic><topic>Chronic restraint stress</topic><topic>Depressive-like behaviour</topic><topic>Dysbacteriosis</topic><topic>Dysbiosis</topic><topic>Gastrointestinal Microbiome</topic><topic>Gut microbiota</topic><topic>Gut-brain axis</topic><topic>Immobilization</topic><topic>Intestinal microflora</topic><topic>Locomotor activity</topic><topic>Microbiota</topic><topic>Mucosa</topic><topic>Oligopeptides</topic><topic>Peptides</topic><topic>Proline - analogs & derivatives</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vorvul, Anton O.</creatorcontrib><creatorcontrib>Bobyntsev, Igor I.</creatorcontrib><creatorcontrib>Medvedeva, Olga A.</creatorcontrib><creatorcontrib>Mukhina, Alexandra Y.</creatorcontrib><creatorcontrib>Svishcheva, Maria V.</creatorcontrib><creatorcontrib>Azarova, Iuliia E.</creatorcontrib><creatorcontrib>Andreeva, Lyudmila A.</creatorcontrib><creatorcontrib>Myasoedov, Nikolay F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropeptides (Edinburgh)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vorvul, Anton O.</au><au>Bobyntsev, Igor I.</au><au>Medvedeva, Olga A.</au><au>Mukhina, Alexandra Y.</au><au>Svishcheva, Maria V.</au><au>Azarova, Iuliia E.</au><au>Andreeva, Lyudmila A.</au><au>Myasoedov, Nikolay F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ACTH(6-9)-Pro-Gly-Pro ameliorates anxiety-like and depressive-like behaviour and gut mucosal microbiota composition in rats under conditions of chronic restraint stress</atitle><jtitle>Neuropeptides (Edinburgh)</jtitle><addtitle>Neuropeptides</addtitle><date>2022-06</date><risdate>2022</risdate><volume>93</volume><spage>102247</spage><epage>102247</epage><pages>102247-102247</pages><artnum>102247</artnum><issn>0143-4179</issn><eissn>1532-2785</eissn><abstract>The effects of the peptide ACTH(6–9)-Pro-Gly-Pro at doses of 5; 50; 500 μg/kg on the Wistar rats' behaviour and gut mucosal microbiota composition under conditions of chronic immobilization stress (CRS) were studied. CRS increased anxiety-like and depressive-like behaviour, disturbances in locomotor activity and gut dysbiosis. Administration of ACTH(6–9)-Pro-Gly-Pro showed many phenotypic results. Peptide demonstrated anti-depressant activity at doses of 5 and 500 μg/kg by a decrease in the total immobile time in the FST. ACTH(6–9)-Pro-Gly-Pro administered at a dose of 50 μg/kg resulted in an anxiolytic effect which is shown by an increase in the time in the open arms of EPM (p < 0.05) and a decrease in the time in the closed arms (p < 0.05). Moreover, the peptide led to a decrease in alpha- and beta-diversity of the gut microbiota (p < 0.01). Correlation and linear regression analysis demonstrated central mechanisms of ACTH(6–9)-Pro-Gly-Pro anxiolytic activity and both central and peripheral ones in an anti-depressant effect. In this way, peptide ACTH(6–9)-Pro-Gly-Pro could prevent the development of behavioural disturbances and gut dysbiosis caused by chronic restraint stress.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>35487169</pmid><doi>10.1016/j.npep.2022.102247</doi><tpages>1</tpages></addata></record> |
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| ispartof | Neuropeptides (Edinburgh), 2022-06, Vol.93, p.102247-102247, Article 102247 |
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| subjects | ACTH(6–9)-Pro-Gly-Pro Adrenocorticotropic hormone Adrenocorticotropic Hormone - pharmacology Animals Anxiety Anxiety - drug therapy Anxiety-like behaviour Behavior, Animal Chronic restraint stress Depressive-like behaviour Dysbacteriosis Dysbiosis Gastrointestinal Microbiome Gut microbiota Gut-brain axis Immobilization Intestinal microflora Locomotor activity Microbiota Mucosa Oligopeptides Peptides Proline - analogs & derivatives Rats Rats, Wistar |
| title | ACTH(6-9)-Pro-Gly-Pro ameliorates anxiety-like and depressive-like behaviour and gut mucosal microbiota composition in rats under conditions of chronic restraint stress |
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