ACTH(6-9)-Pro-Gly-Pro ameliorates anxiety-like and depressive-like behaviour and gut mucosal microbiota composition in rats under conditions of chronic restraint stress

The effects of the peptide ACTH(6–9)-Pro-Gly-Pro at doses of 5; 50; 500 μg/kg on the Wistar rats' behaviour and gut mucosal microbiota composition under conditions of chronic immobilization stress (CRS) were studied. CRS increased anxiety-like and depressive-like behaviour, disturbances in loco...

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Veröffentlicht in:Neuropeptides (Edinburgh) 2022-06, Vol.93, p.102247-102247, Article 102247
Hauptverfasser: Vorvul, Anton O., Bobyntsev, Igor I., Medvedeva, Olga A., Mukhina, Alexandra Y., Svishcheva, Maria V., Azarova, Iuliia E., Andreeva, Lyudmila A., Myasoedov, Nikolay F.
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Sprache:eng
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Zusammenfassung:The effects of the peptide ACTH(6–9)-Pro-Gly-Pro at doses of 5; 50; 500 μg/kg on the Wistar rats' behaviour and gut mucosal microbiota composition under conditions of chronic immobilization stress (CRS) were studied. CRS increased anxiety-like and depressive-like behaviour, disturbances in locomotor activity and gut dysbiosis. Administration of ACTH(6–9)-Pro-Gly-Pro showed many phenotypic results. Peptide demonstrated anti-depressant activity at doses of 5 and 500 μg/kg by a decrease in the total immobile time in the FST. ACTH(6–9)-Pro-Gly-Pro administered at a dose of 50 μg/kg resulted in an anxiolytic effect which is shown by an increase in the time in the open arms of EPM (p 
ISSN:0143-4179
1532-2785
DOI:10.1016/j.npep.2022.102247