Effects of ABCB1 DNA methylation in donors on tacrolimus blood concentrations in recipients following liver transplantation
Aims To investigate the effects of ABCB1 DNA methylation in donors on individual differences in tacrolimus blood concentrations following liver transplantation. Methods Twenty‐three donor liver samples carrying the CYP3A5*3/*3 genotype were classified into 2 groups based on their initial tacrolimus...
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| Veröffentlicht in: | British journal of clinical pharmacology 2022-10, Vol.88 (10), p.4505-4514 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | Aims
To investigate the effects of ABCB1 DNA methylation in donors on individual differences in tacrolimus blood concentrations following liver transplantation.
Methods
Twenty‐three donor liver samples carrying the CYP3A5*3/*3 genotype were classified into 2 groups based on their initial tacrolimus blood concentrations (C0 >10 μg/L or |
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| ISSN: | 0306-5251 1365-2125 |
| DOI: | 10.1111/bcp.15376 |