SAR Analysis of Heterocyclic Compounds with Monocyclic and Bicyclic Structures as Antifungal Agents

Infections caused by eukaryotic organisms, such as fungi, are generally more difficult to treat than bacterial infections. With the widespread use of antifungal drugs in humans and plants, resistance and toxicity have emerged. Therefore, it is desirable to develop new antifungal drugs with low toxicity that are not susceptible to the development of resistance. This review presents a summary of the past few years (2017–2021) of research on heterocyclic compounds as antifungal agents for use in humans and plants, focusing on the structure‐activity relationships (SAR) of these compounds. This review may provide ideas and information for designing and developing new antifungal drugs with fewer side effects compared with currently available drugs. With the development of antifungal drugs, more and more antifungal compounds with excellent antifungal activity have been discovered and achieved good effects. In this article, progress in the development of heterocyclic compounds as antifungal drugs and plant pesticides between 2017 and 2021 is reviewed from the perspective of monocyclic and bicyclic compounds, and the antifungal activity against various fungi is discussed.