Temporal trends in ocular manifestations of HIV/AIDS patients in the past 18 years in a tertiary hospital in China

Purpose To investigate the ocular manifestation changes in human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) patents in a tertiary eye clinic in China over the past 18 years. Methods In this retrospective cross-sectional study, 264 HIV/AIDS patients (528 eyes) were recruited at the Department of Ophthalmology, Peking Union Medical College Hospital, from 2001 to 2018. Patients underwent ophthalmic examinations, including best-corrected visual acuity (BCVA), slit-lamp microscopy, and indirect ophthalmoscopy, and completed a registration form including demographic characteristics, medical history, and immune status data. Kruskal–Wallis test or Mann–Whitney test was used to compare continuous variables, and Pearson’s chi-squared test or Fisher’s exact test was performed to compare categorical variables. Results Regarding demographic characteristics, there was a significant increasing trend in male patients, sexual transmission, and HIV/AIDS–syphilis coinfection (all P