Supramolecularly regulated artificial transmembrane signal transduction for 'ON/OFF'-switchable enzyme catalysis

Supramolecularly regulated artificial transmembrane signal transduction for 'ON/OFF'-switchable enzyme catalysis

An artificial signal transduction model with a supramolecular recognition headgroup, a membrane anchoring group, and a pro-enzyme catalysis endgroup was constructed. The transmembrane translocation of the transducer can be reversibly regulated by competitive host-guest complexations as an input sign...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-05, Vol.58 (38), p.5725-5728
Hauptverfasser: Hou, Jinxing, Jiang, Xiaojia, Yang, Feihu, Wang, Liang, Yan, Tengfei, Liu, Shengda, Xu, Jiayun, Hou, Chunxi, Luo, Quan, Liu, Junqiu
Format: Artikel
Sprache:eng
Schlagworte:
Catalysis
Enzymes
Lipids
Signal transduction
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Zusammenfassung:An artificial signal transduction model with a supramolecular recognition headgroup, a membrane anchoring group, and a pro-enzyme catalysis endgroup was constructed. The transmembrane translocation of the transducer can be reversibly regulated by competitive host-guest complexations as an input signal to control an enzyme reaction inside the lipid vesicles.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc01421a