The role of mechanosensitive Piezo1 channel in diseases
Mechanotransduction is associated with organ development and homoeostasis. Piezo1 and Piezo2 are novel mechanosensitive ion channels (MSCs) in mammals. MSCs are membrane proteins that are critical for the mechanotransduction of living cells. Current studies have demonstrated that the Piezo protein f...
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| Veröffentlicht in: | Progress in biophysics and molecular biology 2022-08, Vol.172, p.39-49 |
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| container_title | Progress in biophysics and molecular biology |
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| creator | Song, Siqi Zhang, Hong Wang, Xiaoya Chen, Wei Cao, Wenxuan Zhang, Zhe Shi, Chunying |
| description | Mechanotransduction is associated with organ development and homoeostasis. Piezo1 and Piezo2 are novel mechanosensitive ion channels (MSCs) in mammals. MSCs are membrane proteins that are critical for the mechanotransduction of living cells. Current studies have demonstrated that the Piezo protein family not only functions in volume regulation, cellular migration, proliferation, and apoptosis but is also important for human diseases of various systems. The complete loss of Piezo1 and Piezo2 function is fatal in the embryonic period. This review summarizes the role of Piezo1 in diseases of different systems and perspectives potential treatments related to Piezo1 for these diseases. |
| doi_str_mv | 10.1016/j.pbiomolbio.2022.04.006 |
| format | Article |
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Piezo1 and Piezo2 are novel mechanosensitive ion channels (MSCs) in mammals. MSCs are membrane proteins that are critical for the mechanotransduction of living cells. Current studies have demonstrated that the Piezo protein family not only functions in volume regulation, cellular migration, proliferation, and apoptosis but is also important for human diseases of various systems. The complete loss of Piezo1 and Piezo2 function is fatal in the embryonic period. This review summarizes the role of Piezo1 in diseases of different systems and perspectives potential treatments related to Piezo1 for these diseases.</description><identifier>ISSN: 0079-6107</identifier><identifier>EISSN: 1873-1732</identifier><identifier>DOI: 10.1016/j.pbiomolbio.2022.04.006</identifier><identifier>PMID: 35436566</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Animals ; Cell Movement ; Genetic diseases ; Humans ; Ion channel ; Ion Channels - metabolism ; Mammals - metabolism ; Mechanical force ; Mechanotransduction, Cellular ; Membrane Proteins - metabolism ; Piezo1 ; Potential treatments</subject><ispartof>Progress in biophysics and molecular biology, 2022-08, Vol.172, p.39-49</ispartof><rights>2022 Elsevier Ltd</rights><rights>Copyright © 2022 Elsevier Ltd. 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Piezo1 and Piezo2 are novel mechanosensitive ion channels (MSCs) in mammals. MSCs are membrane proteins that are critical for the mechanotransduction of living cells. Current studies have demonstrated that the Piezo protein family not only functions in volume regulation, cellular migration, proliferation, and apoptosis but is also important for human diseases of various systems. The complete loss of Piezo1 and Piezo2 function is fatal in the embryonic period. This review summarizes the role of Piezo1 in diseases of different systems and perspectives potential treatments related to Piezo1 for these diseases.</description><subject>Animals</subject><subject>Cell Movement</subject><subject>Genetic diseases</subject><subject>Humans</subject><subject>Ion channel</subject><subject>Ion Channels - metabolism</subject><subject>Mammals - metabolism</subject><subject>Mechanical force</subject><subject>Mechanotransduction, Cellular</subject><subject>Membrane Proteins - metabolism</subject><subject>Piezo1</subject><subject>Potential treatments</subject><issn>0079-6107</issn><issn>1873-1732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PwzAMhiMEYmPwF1COXFqcjybdESa-pElwGOcoS10tU9uMpJsEv55OG3DkYkvW89ryQwhlkDNg6nadb5Y-tKEZas6B8xxkDqBOyJiVWmRMC35KxgB6mikGekQuUloDAGdanZORKKRQhVJjohcrpDE0SENNW3Qr24WEXfK93yF98_gVGN1PO2yo72jlE9qE6ZKc1bZJeHXsE_L--LCYPWfz16eX2d08c0LLPpPTwiFwwRXoQpSFRVFNNa91bZXg0jlXQaHQWSW1mIJUXFqmmbaitAx5KSbk5rB3E8PHFlNvWp8cNo3tMGyT4argRSlBwICWB9TFkFLE2myib238NAzMXptZmz9tZq_NgDSDtiF6fbyyXbZY_QZ_PA3A_QHA4dedx2iS89g5rHxE15sq-P-vfAMdhoGp</recordid><startdate>202208</startdate><enddate>202208</enddate><creator>Song, Siqi</creator><creator>Zhang, Hong</creator><creator>Wang, Xiaoya</creator><creator>Chen, Wei</creator><creator>Cao, Wenxuan</creator><creator>Zhang, Zhe</creator><creator>Shi, Chunying</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7640-9062</orcidid></search><sort><creationdate>202208</creationdate><title>The role of mechanosensitive Piezo1 channel in diseases</title><author>Song, Siqi ; Zhang, Hong ; Wang, Xiaoya ; Chen, Wei ; Cao, Wenxuan ; Zhang, Zhe ; Shi, Chunying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-495ce02326075385ae3d972f7fa6324cccd056eca6473904624a1717a38a1e283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Cell Movement</topic><topic>Genetic diseases</topic><topic>Humans</topic><topic>Ion channel</topic><topic>Ion Channels - metabolism</topic><topic>Mammals - metabolism</topic><topic>Mechanical force</topic><topic>Mechanotransduction, Cellular</topic><topic>Membrane Proteins - metabolism</topic><topic>Piezo1</topic><topic>Potential treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Siqi</creatorcontrib><creatorcontrib>Zhang, Hong</creatorcontrib><creatorcontrib>Wang, Xiaoya</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Cao, Wenxuan</creatorcontrib><creatorcontrib>Zhang, Zhe</creatorcontrib><creatorcontrib>Shi, Chunying</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in biophysics and molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Siqi</au><au>Zhang, Hong</au><au>Wang, Xiaoya</au><au>Chen, Wei</au><au>Cao, Wenxuan</au><au>Zhang, Zhe</au><au>Shi, Chunying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of mechanosensitive Piezo1 channel in diseases</atitle><jtitle>Progress in biophysics and molecular biology</jtitle><addtitle>Prog Biophys Mol Biol</addtitle><date>2022-08</date><risdate>2022</risdate><volume>172</volume><spage>39</spage><epage>49</epage><pages>39-49</pages><issn>0079-6107</issn><eissn>1873-1732</eissn><abstract>Mechanotransduction is associated with organ development and homoeostasis. 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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Movement Genetic diseases Humans Ion channel Ion Channels - metabolism Mammals - metabolism Mechanical force Mechanotransduction, Cellular Membrane Proteins - metabolism Piezo1 Potential treatments |
| title | The role of mechanosensitive Piezo1 channel in diseases |
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