The role of mechanosensitive Piezo1 channel in diseases

The role of mechanosensitive Piezo1 channel in diseases

Mechanotransduction is associated with organ development and homoeostasis. Piezo1 and Piezo2 are novel mechanosensitive ion channels (MSCs) in mammals. MSCs are membrane proteins that are critical for the mechanotransduction of living cells. Current studies have demonstrated that the Piezo protein f...

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Veröffentlicht in:Progress in biophysics and molecular biology 2022-08, Vol.172, p.39-49
Hauptverfasser: Song, Siqi, Zhang, Hong, Wang, Xiaoya, Chen, Wei, Cao, Wenxuan, Zhang, Zhe, Shi, Chunying
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Movement
Genetic diseases
Humans
Ion channel
Ion Channels - metabolism
Mammals - metabolism
Mechanical force
Mechanotransduction, Cellular
Membrane Proteins - metabolism
Piezo1
Potential treatments
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Zusammenfassung:Mechanotransduction is associated with organ development and homoeostasis. Piezo1 and Piezo2 are novel mechanosensitive ion channels (MSCs) in mammals. MSCs are membrane proteins that are critical for the mechanotransduction of living cells. Current studies have demonstrated that the Piezo protein family not only functions in volume regulation, cellular migration, proliferation, and apoptosis but is also important for human diseases of various systems. The complete loss of Piezo1 and Piezo2 function is fatal in the embryonic period. This review summarizes the role of Piezo1 in diseases of different systems and perspectives potential treatments related to Piezo1 for these diseases.
ISSN:0079-6107
1873-1732
DOI:10.1016/j.pbiomolbio.2022.04.006