Predictors of Expiratory Flow Limitation during Exercise in Healthy Males and Females

To determine which factors predispose individuals to EFL during exercise and whether these factors differ based on sex. We hypothesized that: i) EFL frequency would be similar in males and females, and ii) in females, EFL would be associated with indices of low ventilatory capacity, whereas in males, EFL would be associated with indices of high ventilatory demand. Data from n = 126 healthy adults (20-45 y, n = 60 males, n = 66 females) with a wide range of cardiorespiratory fitness (81-182 %-predicted maximal oxygen uptake) were included in the study. Participants performed spirometry and an incremental cycle exercise test to exhaustion. Standard cardiorespiratory variables were assessed throughout exercise. The tidal flow-volume overlap method was used to assess EFL based on a minimum threshold of 5% overlap between the tidal and maximum expiratory flow-volume curves. Predictors of EFL during exercise were determined via multiple logistical regression using anthropometric, pulmonary function, and peak exercise data. During exercise, EFL occurred in 49% of participants and was similar between the sexes (females = 45%, males = 53%; p = 0.48). In males, low forced expired flow between 25-75% of forced vital capacity and high slope-ratio (SR), as well as low end-expiratory lung volume, high breathing frequency (Fb) and high relative tidal volume (VT) at peak exercise were associated with EFL (p < 0.001; Nagelkerke R2 = 0.73). In females, high SR, high Fb, and VT at peak exercise were associated with EFL (p < 0.001; Nagelkerke R2 = 0.61). Despite sex-differences in respiratory system morphology, the frequency and predictors of EFL during exercise do not substantially differ between the sexes.