Antibiotic natural product hunanamycin A: Lead identification towards anti-Salmonella agents

Design and synthesis of library of compounds around the antibiotic natural product hunanamycin A scaffold and their biological evaluation are disclosed here. These efforts resulted in identification of a lead compound 36, which is a structurally simplified analogue of original hunanamycin A with impressive activity against Salmonella enterica and possesses other druggable properties. In addition, no acute oral toxicity was observed for compound 36 in Swiss albino mice dosed up to 2 g/kg. It has the potential to be developed for the treatment of food infections caused by Salmonella. [Display omitted] •Designed and synthesized >70 analogues of antibiotic natural product hunanamycin A and screened against Salmonella enterica.•Identified of four inhibitors 27, 40, 36, and 62 more potent than HA and established valuable SARs.•Lead compound 36, a simplified analogue possesses impressive activity against S. enterica with decent in vitro ADME profile.•No acute oral toxicity was observed for compound 36 in Swiss albino mice dosed up to 2 g/Kg.