High rate of Clostridioides difficile colonization in patients admitted to intensive care: A prospective cohort study

Here, we evaluated the frequency of C. difficile colonization and its impact on clinical outcomes in patients admitted to intensive care units in Brazil. From ninety-two patients screened 16 (17.3%) were colonized by C. difficile. Colonized patients had higher Simplified Acute Physiology Score III (SAPS III), however there was no association between C. difficile colonization with diarrhea or mortality. The C. difficile strains sequenced belonged to clade 1 and presented high vancomycin-resistant rates. 1.Prospective cohort study in adult ICUs of two tertiary teaching hospitals in Brazil2.Evaluate the C. difficile colonization, variables associated, and the clinical course of colonized patients3.The colonization rate was 17.3% and it was associated with higher SAPS III score4.All recovered strains belonged to clade 1 and presented high resistance levels to vancomycin