Phytochemical investigation of the fruits of Xanthium strumarium and their cytotoxic activity

Eight pentacyclic triterpenoids including two new ones ( 1 , 2 ) were isolated from the fruits of Xanthium strumarium . Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated for in vitro cytotoxic activity on HepG2, A549, HCT116 and SW480 cancer cells. Amo...

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Veröffentlicht in:	Journal of natural medicines 2022-03, Vol.76 (2), p.468-475
Hauptverfasser:	Xu, Xiang-Wei, Xi, Yi-Yuan, Chen, Jun, Zhang, Feng, Zheng, Ju-Jia, Zhang, Peng-Hai
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin V Antifungal agents Antineoplastic Agents Biomedical and Life Sciences Biomedicine Cell cycle cell cycle checkpoints Cell death Complementary & Alternative Medicine Cytotoxicity death Fruit G1 phase interphase Medicinal Chemistry Pentacyclic triterpenoids Pharmacology/Toxicology Pharmacy phytochemicals Phytochemicals - pharmacology Plant Sciences spectral analysis Triterpenoids Xanthium - chemistry Xanthium strumarium
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Zusammenfassung:	Eight pentacyclic triterpenoids including two new ones ( 1 , 2 ) were isolated from the fruits of Xanthium strumarium . Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated for in vitro cytotoxic activity on HepG2, A549, HCT116 and SW480 cancer cells. Among them, the new compound 2 was found to exhibit significant cytotoxic activity on A549, HCT116 and SW480 cancer cells with IC 50 values of 9.68, 4.27 and 7.58 μM, respectively. Further, 2 was selected for cell cycle analysis and results revealed that 2 could cause HCT116 cell cycle arrest in G1 phase. In addition, Annexin V-FITC/PI staining assay showed that 2 could induce the death of HCT116 cells. Graphical abstract
ISSN:	1340-3443 1861-0293
DOI:	10.1007/s11418-021-01588-w