An approach for the scalable production of macroporous polymer beads
[Display omitted] A tubular co-flow reactor to produce macroporous polymer beads by polymerization of medium and high internal phase emulsion (M/HIPE) templates was developed. This reactor allows for improved production rates compared to tubing based microfluidic devices. Water-in-oil (W/O) M/HIPEs,...
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| Veröffentlicht in: | Journal of colloid and interface science 2022-06, Vol.616, p.834-845 |
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| container_title | Journal of colloid and interface science |
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| creator | Ferrer, Juan Jiang, Qixiang Menner, Angelika Bismarck, Alexander |
| description | [Display omitted]
A tubular co-flow reactor to produce macroporous polymer beads by polymerization of medium and high internal phase emulsion (M/HIPE) templates was developed. This reactor allows for improved production rates compared to tubing based microfluidic devices. Water-in-oil (W/O) M/HIPEs, containing methyl methacrylate (MMA) and ethylene glycol dimethacrylate (EGDMA) monomers in the continuous phase, were injected into a re-circulating carrier phase. The continuous phase of the emulsion droplets was UV polymerized in situ, resulting in polyM/HIPE beads. The emulsion composition was adjusted to produce poly(MMA-co-EGDMA) porous polymer beads with a protective crust and an interconnected internal pore structure. HCl loaded beads were produced by adding the active ingredient into the dispersed emulsion phase, leading to HCl encapsulation in the porous structure of the beads after polymerization. Even after exposure to ambient conditions for 24 h, 60% of the HCl remained in the beads, indicating good encapsulation efficiencies. Thus, it is possible to use such macroporous beads as delivery vehicles. |
| doi_str_mv | 10.1016/j.jcis.2022.02.053 |
| format | Article |
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A tubular co-flow reactor to produce macroporous polymer beads by polymerization of medium and high internal phase emulsion (M/HIPE) templates was developed. This reactor allows for improved production rates compared to tubing based microfluidic devices. Water-in-oil (W/O) M/HIPEs, containing methyl methacrylate (MMA) and ethylene glycol dimethacrylate (EGDMA) monomers in the continuous phase, were injected into a re-circulating carrier phase. The continuous phase of the emulsion droplets was UV polymerized in situ, resulting in polyM/HIPE beads. The emulsion composition was adjusted to produce poly(MMA-co-EGDMA) porous polymer beads with a protective crust and an interconnected internal pore structure. HCl loaded beads were produced by adding the active ingredient into the dispersed emulsion phase, leading to HCl encapsulation in the porous structure of the beads after polymerization. Even after exposure to ambient conditions for 24 h, 60% of the HCl remained in the beads, indicating good encapsulation efficiencies. Thus, it is possible to use such macroporous beads as delivery vehicles.</description><identifier>ISSN: 0021-9797</identifier><identifier>EISSN: 1095-7103</identifier><identifier>DOI: 10.1016/j.jcis.2022.02.053</identifier><identifier>PMID: 35248970</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>active ingredients ; Beads ; Clogging ; Emulsion templating ; emulsions ; Emulsions - chemistry ; encapsulation ; ethylene glycol ; Macroporous polymer ; Microfluidic ; Polymer particles ; Polymerization ; polymers ; Polymers - chemistry ; Porosity ; porous media ; Water - chemistry</subject><ispartof>Journal of colloid and interface science, 2022-06, Vol.616, p.834-845</ispartof><rights>2022 The Author(s)</rights><rights>Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-dc814e7c50d159a9c754fad7ccd84d17e413398b36db60ac07e365460bdc72643</citedby><cites>FETCH-LOGICAL-c433t-dc814e7c50d159a9c754fad7ccd84d17e413398b36db60ac07e365460bdc72643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S002197972200279X$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35248970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ferrer, Juan</creatorcontrib><creatorcontrib>Jiang, Qixiang</creatorcontrib><creatorcontrib>Menner, Angelika</creatorcontrib><creatorcontrib>Bismarck, Alexander</creatorcontrib><title>An approach for the scalable production of macroporous polymer beads</title><title>Journal of colloid and interface science</title><addtitle>J Colloid Interface Sci</addtitle><description>[Display omitted]
A tubular co-flow reactor to produce macroporous polymer beads by polymerization of medium and high internal phase emulsion (M/HIPE) templates was developed. This reactor allows for improved production rates compared to tubing based microfluidic devices. Water-in-oil (W/O) M/HIPEs, containing methyl methacrylate (MMA) and ethylene glycol dimethacrylate (EGDMA) monomers in the continuous phase, were injected into a re-circulating carrier phase. The continuous phase of the emulsion droplets was UV polymerized in situ, resulting in polyM/HIPE beads. The emulsion composition was adjusted to produce poly(MMA-co-EGDMA) porous polymer beads with a protective crust and an interconnected internal pore structure. HCl loaded beads were produced by adding the active ingredient into the dispersed emulsion phase, leading to HCl encapsulation in the porous structure of the beads after polymerization. Even after exposure to ambient conditions for 24 h, 60% of the HCl remained in the beads, indicating good encapsulation efficiencies. Thus, it is possible to use such macroporous beads as delivery vehicles.</description><subject>active ingredients</subject><subject>Beads</subject><subject>Clogging</subject><subject>Emulsion templating</subject><subject>emulsions</subject><subject>Emulsions - chemistry</subject><subject>encapsulation</subject><subject>ethylene glycol</subject><subject>Macroporous polymer</subject><subject>Microfluidic</subject><subject>Polymer particles</subject><subject>Polymerization</subject><subject>polymers</subject><subject>Polymers - chemistry</subject><subject>Porosity</subject><subject>porous media</subject><subject>Water - chemistry</subject><issn>0021-9797</issn><issn>1095-7103</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1L7TAQhoNc0ePHH3AhWbrpcdIkTQtuxG8Q3Og6pJMp9tCe9CY9gv_eHI7XpVwYGBieeZl5GDsTsBQgqsvVcoV9WpZQlkvIpeUeWwhodGEEyD9sAVCKojGNOWRHKa0AhNC6OWCHUpeqbgws2O31mrtpisHhO-9C5PM78YRucO1APM_9Buc-rHno-OgwhinEsEl8CsPnSJG35Hw6YfudGxKdfvdj9nZ_93rzWDy_PDzdXD8XqKScC4-1UGRQgxe6cQ0arTrnDaKvlReGlJCyqVtZ-bYCh2BIVlpV0Ho0ZaXkMbvY5ea7_m4ozXbsE9IwuDXlo2xm6lqDEvV_oLLKbF3JjJY7NH-XUqTOTrEfXfy0AuxWtF3ZrWi7FW0hl94unX_nb9qR_M_KP7MZuNoBlIV89BRtwp7WSL6PhLP1of8t_wuG844p</recordid><startdate>20220615</startdate><enddate>20220615</enddate><creator>Ferrer, Juan</creator><creator>Jiang, Qixiang</creator><creator>Menner, Angelika</creator><creator>Bismarck, Alexander</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20220615</creationdate><title>An approach for the scalable production of macroporous polymer beads</title><author>Ferrer, Juan ; Jiang, Qixiang ; Menner, Angelika ; Bismarck, Alexander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-dc814e7c50d159a9c754fad7ccd84d17e413398b36db60ac07e365460bdc72643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>active ingredients</topic><topic>Beads</topic><topic>Clogging</topic><topic>Emulsion templating</topic><topic>emulsions</topic><topic>Emulsions - chemistry</topic><topic>encapsulation</topic><topic>ethylene glycol</topic><topic>Macroporous polymer</topic><topic>Microfluidic</topic><topic>Polymer particles</topic><topic>Polymerization</topic><topic>polymers</topic><topic>Polymers - chemistry</topic><topic>Porosity</topic><topic>porous media</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ferrer, Juan</creatorcontrib><creatorcontrib>Jiang, Qixiang</creatorcontrib><creatorcontrib>Menner, Angelika</creatorcontrib><creatorcontrib>Bismarck, Alexander</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Journal of colloid and interface science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ferrer, Juan</au><au>Jiang, Qixiang</au><au>Menner, Angelika</au><au>Bismarck, Alexander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An approach for the scalable production of macroporous polymer beads</atitle><jtitle>Journal of colloid and interface science</jtitle><addtitle>J Colloid Interface Sci</addtitle><date>2022-06-15</date><risdate>2022</risdate><volume>616</volume><spage>834</spage><epage>845</epage><pages>834-845</pages><issn>0021-9797</issn><eissn>1095-7103</eissn><abstract>[Display omitted]
A tubular co-flow reactor to produce macroporous polymer beads by polymerization of medium and high internal phase emulsion (M/HIPE) templates was developed. This reactor allows for improved production rates compared to tubing based microfluidic devices. Water-in-oil (W/O) M/HIPEs, containing methyl methacrylate (MMA) and ethylene glycol dimethacrylate (EGDMA) monomers in the continuous phase, were injected into a re-circulating carrier phase. The continuous phase of the emulsion droplets was UV polymerized in situ, resulting in polyM/HIPE beads. The emulsion composition was adjusted to produce poly(MMA-co-EGDMA) porous polymer beads with a protective crust and an interconnected internal pore structure. HCl loaded beads were produced by adding the active ingredient into the dispersed emulsion phase, leading to HCl encapsulation in the porous structure of the beads after polymerization. Even after exposure to ambient conditions for 24 h, 60% of the HCl remained in the beads, indicating good encapsulation efficiencies. Thus, it is possible to use such macroporous beads as delivery vehicles.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>35248970</pmid><doi>10.1016/j.jcis.2022.02.053</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of colloid and interface science, 2022-06, Vol.616, p.834-845 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | active ingredients Beads Clogging Emulsion templating emulsions Emulsions - chemistry encapsulation ethylene glycol Macroporous polymer Microfluidic Polymer particles Polymerization polymers Polymers - chemistry Porosity porous media Water - chemistry |
| title | An approach for the scalable production of macroporous polymer beads |
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