Angiotensin-(1−7), a protective peptide against vascular aging

Vascular aging is a complex and multifaceted process that provokes profound molecular, structural, and functional changes in the vasculature. Eventually, these profound aging alterations make arteries more prone to vascular disease, including hypertension, atherosclerosis and other arterial complications that impact the organism beyond the cardiovascular system and accelerate frailty. For these reasons, preventing or delaying the hallmarks of vascular aging is nowadays a major health goal, especially in our aged societies. In this context, angiotensin(Ang)-(1−7), a major player of the protective branch of the renin-angiotensin system, has gained relevance over recent years as growing knowledge on its anti-aging properties is being unveiled. Here, we briefly review the main actions of Ang-(1−7) against vascular aging. These include protection against vascular cell senescence, anti-inflammatory and antioxidant effects together with the induction of cytoprotective systems. Ang-(1−7) further ameliorates endothelial dysfunction, a hallmark of vascular aging and disease, attenuates fibrosis and calcification and promotes protective angiogenesis and repair. Although further research is needed to better understand the anti-aging properties of Ang-(1−7) on the vasculature, this heptapeptide arises as a promising pharmacological tool for preventing vascular aging and frailty. [Display omitted] •Vascular aging is a complex and multifaceted process that promotes vascular disease and frailty.•Angiotensin-(1−7) has recently emerged as an agent capable to delay vascular aging.•This heptapeptide counteracts hallmarks of aging such as cell senescence and inflammaging.•As we age, the endogenous production of protective angiotensin-(1−7) is reduced.•Angiotensin-(1−7) supplementation may be therapeutically useful in age-related vascular diseases.