Longitudinal changes in angiogenesis biomarkers within 72 h of diagnosis and time-to-delivery in early-onset preeclampsia
•In women with diagnosis of early preeclampsia.•Time to delivery is associated with incremental sFlt-1/PlGF values after 72 h (Δ 72h).•Δ 72h sFlt-1/PlGF > 3rd quartile shows a significant reduction of time-to-delivery.•Δ 72h sFlt-1/PlGF ≤ 0 (28% of cases) has a median time-to-delivery of 2 weeks....
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| Veröffentlicht in: | Pregnancy hypertension 2022-06, Vol.28, p.139-145 |
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| creator | Villalain, Cecilia Gómez-Arriaga, Paula Simón, Elisa Galindo, Alberto Herraiz, Ignacio |
| description | •In women with diagnosis of early preeclampsia.•Time to delivery is associated with incremental sFlt-1/PlGF values after 72 h (Δ 72h).•Δ 72h sFlt-1/PlGF > 3rd quartile shows a significant reduction of time-to-delivery.•Δ 72h sFlt-1/PlGF ≤ 0 (28% of cases) has a median time-to-delivery of 2 weeks.•All abruptio placentae occurred with PlGF 3rd expected quartile or Δ72h PlGF 3rd quartile had a significant reduction of time-to-delivery when compared to increments |
| doi_str_mv | 10.1016/j.preghy.2022.03.009 |
| format | Article |
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To evaluate the association between the increment of the sFlt-1/PlGF ratio within the first 72 h after the diagnosis of early-onset preeclampsia (PE) and the time-to-delivery. Secondarily we aimed to test its predictive value for maternal adverse outcomes.
Retrospective cohort study of 155 women with early-onset PE and measurement of sFlt-1/PlGF at diagnosis and delivery from which the expected distributions of the daily increment (Δ) of sFlt-1/PlGF ratio, sFlt-1 and PlGF were obtained. Of them, in 110 a short-term evaluation at 72 +/− 24 h was available and Δ72h were calculated and compared to the expected distributions. The high-risk groups were those with Δ72h sFlt-1/PlGF and Δ72h sFlt-1 > 3rd expected quartile or Δ72h PlGF < 1st expected quartile. The low-risk groups were those with Δ72h ≤ 0 for sFlt-1/PlGF and sFlt-1 or Δ72h PlGF ≥ 0. The rest were considered intermediate risk.
Time-to-delivery and maternal adverse outcomes were compared between the three groups.
Δ72h sFlt-1/PlGF and sFlt-1 > 3rd quartile had a significant reduction of time-to-delivery when compared to increments < 3rd quartile or ≤ 0 (5 vs 11 vs 14 days, p < 0.01) and (6 vs 8 vs 15 days, p < 0.01), respectively. Both were limited for the prediction of maternal adverse outcomes. Δ72h PlGF showed no significant relation with time-to-deliver but all abruptio placentae had PlGF < 70 pg/mL at diagnosis.
High Δ72h sFlt-1/PlGF and sFlt-1 are associated to a shorter time-to-delivery while low PlGF at diagnosis is associated to abruptio placentae.]]></description><identifier>ISSN: 2210-7789</identifier><identifier>EISSN: 2210-7797</identifier><identifier>DOI: 10.1016/j.preghy.2022.03.009</identifier><identifier>PMID: 35381472</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Abruptio Placentae ; Angiogenesis biomarkers ; Biomarkers ; Early-onset ; Female ; Humans ; Placenta Growth Factor ; Pre-Eclampsia - diagnosis ; Predictive Value of Tests ; Preeclampsia ; Pregnancy ; Retrospective Studies ; sFlt-1/PlGF ; Time-to-delivery ; Vascular Endothelial Growth Factor Receptor-1</subject><ispartof>Pregnancy hypertension, 2022-06, Vol.28, p.139-145</ispartof><rights>2022 International Society for the Study of Hypertension in Pregnancy</rights><rights>Copyright © 2022 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-d2c94dd8023fd8d8256fba8d6b946324905b4fa0a45cffe475518814148a80623</citedby><cites>FETCH-LOGICAL-c362t-d2c94dd8023fd8d8256fba8d6b946324905b4fa0a45cffe475518814148a80623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.preghy.2022.03.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35381472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Villalain, Cecilia</creatorcontrib><creatorcontrib>Gómez-Arriaga, Paula</creatorcontrib><creatorcontrib>Simón, Elisa</creatorcontrib><creatorcontrib>Galindo, Alberto</creatorcontrib><creatorcontrib>Herraiz, Ignacio</creatorcontrib><title>Longitudinal changes in angiogenesis biomarkers within 72 h of diagnosis and time-to-delivery in early-onset preeclampsia</title><title>Pregnancy hypertension</title><addtitle>Pregnancy Hypertens</addtitle><description><![CDATA[•In women with diagnosis of early preeclampsia.•Time to delivery is associated with incremental sFlt-1/PlGF values after 72 h (Δ 72h).•Δ 72h sFlt-1/PlGF > 3rd quartile shows a significant reduction of time-to-delivery.•Δ 72h sFlt-1/PlGF ≤ 0 (28% of cases) has a median time-to-delivery of 2 weeks.•All abruptio placentae occurred with PlGF < 70 pg/mL at diagnosis.•sFlt-1/PlGF and its components should be evaluated as a dynamic feature.
To evaluate the association between the increment of the sFlt-1/PlGF ratio within the first 72 h after the diagnosis of early-onset preeclampsia (PE) and the time-to-delivery. Secondarily we aimed to test its predictive value for maternal adverse outcomes.
Retrospective cohort study of 155 women with early-onset PE and measurement of sFlt-1/PlGF at diagnosis and delivery from which the expected distributions of the daily increment (Δ) of sFlt-1/PlGF ratio, sFlt-1 and PlGF were obtained. Of them, in 110 a short-term evaluation at 72 +/− 24 h was available and Δ72h were calculated and compared to the expected distributions. The high-risk groups were those with Δ72h sFlt-1/PlGF and Δ72h sFlt-1 > 3rd expected quartile or Δ72h PlGF < 1st expected quartile. The low-risk groups were those with Δ72h ≤ 0 for sFlt-1/PlGF and sFlt-1 or Δ72h PlGF ≥ 0. The rest were considered intermediate risk.
Time-to-delivery and maternal adverse outcomes were compared between the three groups.
Δ72h sFlt-1/PlGF and sFlt-1 > 3rd quartile had a significant reduction of time-to-delivery when compared to increments < 3rd quartile or ≤ 0 (5 vs 11 vs 14 days, p < 0.01) and (6 vs 8 vs 15 days, p < 0.01), respectively. Both were limited for the prediction of maternal adverse outcomes. Δ72h PlGF showed no significant relation with time-to-deliver but all abruptio placentae had PlGF < 70 pg/mL at diagnosis.
High Δ72h sFlt-1/PlGF and sFlt-1 are associated to a shorter time-to-delivery while low PlGF at diagnosis is associated to abruptio placentae.]]></description><subject>Abruptio Placentae</subject><subject>Angiogenesis biomarkers</subject><subject>Biomarkers</subject><subject>Early-onset</subject><subject>Female</subject><subject>Humans</subject><subject>Placenta Growth Factor</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Predictive Value of Tests</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Retrospective Studies</subject><subject>sFlt-1/PlGF</subject><subject>Time-to-delivery</subject><subject>Vascular Endothelial Growth Factor Receptor-1</subject><issn>2210-7789</issn><issn>2210-7797</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhi1ERau2b4CQj1wSbMdxnAsSqqBFWokLnC3HnmRnSezFzhYtT8Oz8GR4taVHfPFI_mbG_0fIa85qzrh6t6v3CabtsRZMiJo1NWP9C3IlBGdV1_Xdy-da95fkNucdK0e2THfqFbls2kZz2Ykr8msTw4TrwWOwM3VbGybIFAMtBcYJAmTMdMC42PQdUqY_cd2W5078-b2lcaQe7RTiCbLB0xUXqNZYeZjxEdLxNAlsmo9VDBlWWn4NbrbLPqO9IRejnTPcPt3X5Nunj1_vHqrNl_vPdx82lWuUWCsvXC-910w0o9dei1aNg9VeDb1UjZA9awc5WmZl68YRZNe2XJd0XGqrmRLNNXl7nrtP8ccB8moWzA7m2QaIh2yEkp1qJRd9QeUZdSnmnGA0-4Ql-dFwZk7izc6cxZuTeMMaU8SXtjdPGw7DAv656Z_mArw_A1ByPiIkkx1CcOAxgVuNj_j_DX8B5uSYNQ</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Villalain, Cecilia</creator><creator>Gómez-Arriaga, Paula</creator><creator>Simón, Elisa</creator><creator>Galindo, Alberto</creator><creator>Herraiz, Ignacio</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202206</creationdate><title>Longitudinal changes in angiogenesis biomarkers within 72 h of diagnosis and time-to-delivery in early-onset preeclampsia</title><author>Villalain, Cecilia ; Gómez-Arriaga, Paula ; Simón, Elisa ; Galindo, Alberto ; Herraiz, Ignacio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-d2c94dd8023fd8d8256fba8d6b946324905b4fa0a45cffe475518814148a80623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abruptio Placentae</topic><topic>Angiogenesis biomarkers</topic><topic>Biomarkers</topic><topic>Early-onset</topic><topic>Female</topic><topic>Humans</topic><topic>Placenta Growth Factor</topic><topic>Pre-Eclampsia - diagnosis</topic><topic>Predictive Value of Tests</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Retrospective Studies</topic><topic>sFlt-1/PlGF</topic><topic>Time-to-delivery</topic><topic>Vascular Endothelial Growth Factor Receptor-1</topic><toplevel>online_resources</toplevel><creatorcontrib>Villalain, Cecilia</creatorcontrib><creatorcontrib>Gómez-Arriaga, Paula</creatorcontrib><creatorcontrib>Simón, Elisa</creatorcontrib><creatorcontrib>Galindo, Alberto</creatorcontrib><creatorcontrib>Herraiz, Ignacio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pregnancy hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Villalain, Cecilia</au><au>Gómez-Arriaga, Paula</au><au>Simón, Elisa</au><au>Galindo, Alberto</au><au>Herraiz, Ignacio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal changes in angiogenesis biomarkers within 72 h of diagnosis and time-to-delivery in early-onset preeclampsia</atitle><jtitle>Pregnancy hypertension</jtitle><addtitle>Pregnancy Hypertens</addtitle><date>2022-06</date><risdate>2022</risdate><volume>28</volume><spage>139</spage><epage>145</epage><pages>139-145</pages><issn>2210-7789</issn><eissn>2210-7797</eissn><abstract><![CDATA[•In women with diagnosis of early preeclampsia.•Time to delivery is associated with incremental sFlt-1/PlGF values after 72 h (Δ 72h).•Δ 72h sFlt-1/PlGF > 3rd quartile shows a significant reduction of time-to-delivery.•Δ 72h sFlt-1/PlGF ≤ 0 (28% of cases) has a median time-to-delivery of 2 weeks.•All abruptio placentae occurred with PlGF < 70 pg/mL at diagnosis.•sFlt-1/PlGF and its components should be evaluated as a dynamic feature.
To evaluate the association between the increment of the sFlt-1/PlGF ratio within the first 72 h after the diagnosis of early-onset preeclampsia (PE) and the time-to-delivery. Secondarily we aimed to test its predictive value for maternal adverse outcomes.
Retrospective cohort study of 155 women with early-onset PE and measurement of sFlt-1/PlGF at diagnosis and delivery from which the expected distributions of the daily increment (Δ) of sFlt-1/PlGF ratio, sFlt-1 and PlGF were obtained. Of them, in 110 a short-term evaluation at 72 +/− 24 h was available and Δ72h were calculated and compared to the expected distributions. The high-risk groups were those with Δ72h sFlt-1/PlGF and Δ72h sFlt-1 > 3rd expected quartile or Δ72h PlGF < 1st expected quartile. The low-risk groups were those with Δ72h ≤ 0 for sFlt-1/PlGF and sFlt-1 or Δ72h PlGF ≥ 0. The rest were considered intermediate risk.
Time-to-delivery and maternal adverse outcomes were compared between the three groups.
Δ72h sFlt-1/PlGF and sFlt-1 > 3rd quartile had a significant reduction of time-to-delivery when compared to increments < 3rd quartile or ≤ 0 (5 vs 11 vs 14 days, p < 0.01) and (6 vs 8 vs 15 days, p < 0.01), respectively. Both were limited for the prediction of maternal adverse outcomes. Δ72h PlGF showed no significant relation with time-to-deliver but all abruptio placentae had PlGF < 70 pg/mL at diagnosis.
High Δ72h sFlt-1/PlGF and sFlt-1 are associated to a shorter time-to-delivery while low PlGF at diagnosis is associated to abruptio placentae.]]></abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>35381472</pmid><doi>10.1016/j.preghy.2022.03.009</doi><tpages>7</tpages></addata></record> |
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| ispartof | Pregnancy hypertension, 2022-06, Vol.28, p.139-145 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Abruptio Placentae Angiogenesis biomarkers Biomarkers Early-onset Female Humans Placenta Growth Factor Pre-Eclampsia - diagnosis Predictive Value of Tests Preeclampsia Pregnancy Retrospective Studies sFlt-1/PlGF Time-to-delivery Vascular Endothelial Growth Factor Receptor-1 |
| title | Longitudinal changes in angiogenesis biomarkers within 72 h of diagnosis and time-to-delivery in early-onset preeclampsia |
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