Longitudinal changes in angiogenesis biomarkers within 72 h of diagnosis and time-to-delivery in early-onset preeclampsia

Longitudinal changes in angiogenesis biomarkers within 72 h of diagnosis and time-to-delivery in early-onset preeclampsia

•In women with diagnosis of early preeclampsia.•Time to delivery is associated with incremental sFlt-1/PlGF values after 72 h (Δ 72h).•Δ 72h sFlt-1/PlGF > 3rd quartile shows a significant reduction of time-to-delivery.•Δ 72h sFlt-1/PlGF ≤ 0 (28% of cases) has a median time-to-delivery of 2 weeks....

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Pregnancy hypertension 2022-06, Vol.28, p.139-145
Hauptverfasser: Villalain, Cecilia, Gómez-Arriaga, Paula, Simón, Elisa, Galindo, Alberto, Herraiz, Ignacio
Format: Artikel
Sprache:eng
Schlagworte:
Abruptio Placentae
Angiogenesis biomarkers
Biomarkers
Early-onset
Female
Humans
Placenta Growth Factor
Pre-Eclampsia - diagnosis
Predictive Value of Tests
Preeclampsia
Pregnancy
Retrospective Studies
sFlt-1/PlGF
Time-to-delivery
Vascular Endothelial Growth Factor Receptor-1
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:•In women with diagnosis of early preeclampsia.•Time to delivery is associated with incremental sFlt-1/PlGF values after 72 h (Δ 72h).•Δ 72h sFlt-1/PlGF > 3rd quartile shows a significant reduction of time-to-delivery.•Δ 72h sFlt-1/PlGF ≤ 0 (28% of cases) has a median time-to-delivery of 2 weeks.•All abruptio placentae occurred with PlGF  3rd expected quartile or Δ72h PlGF  3rd quartile had a significant reduction of time-to-delivery when compared to increments 
ISSN:2210-7789
2210-7797
DOI:10.1016/j.preghy.2022.03.009