Suppression of RPL34 Inhibits Tumor Cell Proliferation and Promotes Apoptosis in Glioblastoma

Accumulating evidence indicates Ribosomal protein 34 (RPL34) promotes tumor malignance and its expression is associated with poor prognosis in multiple cancer cells. However, the physiological role and biological mechanism of RPL34 in glioblastoma (GBM) remain unclear. Hence, this study aimed to inv...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Applied biochemistry and biotechnology 2022-08, Vol.194 (8), p.3494-3506
Hauptverfasser:	Du, Changwang, Wang, Taoning, Jia, Jinning, Li, Junjun, Xiao, Yi, Wang, Jia, Mao, Ping, Wang, Ning, Shi, Luoning, Wang, Maode
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Biochemistry Biotechnology Brain cancer Brain tumors Cell activation Cell growth Cell proliferation Cell survival Chemistry Chemistry and Materials Science Epilepsy Flow cytometry Glioblastoma Glioma Glioma cells Kinases Medical prognosis Metastasis Neurosurgery Original Article Poly(ADP-ribose) polymerase Proteins Reagents Signal transduction Survival Therapeutic targets Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Accumulating evidence indicates Ribosomal protein 34 (RPL34) promotes tumor malignance and its expression is associated with poor prognosis in multiple cancer cells. However, the physiological role and biological mechanism of RPL34 in glioblastoma (GBM) remain unclear. Hence, this study aimed to investigate the expression and the role of RPL34 in GBM. A total of 59 glioma samples and 12 normal brains for epilepsy surgery were used to determine the underlying mechanisms and the biological behaviors of RPL34 in GBM. In this study, we identified that RPL34 expression was significantly ( p
ISSN:	0273-2289 1559-0291
DOI:	10.1007/s12010-022-03857-0