An antioxidant boehmite amino-nanozyme able to disaggregate Huntington's inclusion bodies
A novel amino-nanozyme, based on boehmite nanoparticles (BNPs) functionalised with a tetra-azapyridinophane ( L1 ), has been designed to undermine some of the key issues underlying Huntington disease. L1 forms Cu 2+ complexes with a striking SOD activity, while when grafted to the BNPs displays mito...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2022-04, Vol.58 (32), p.521-524 |
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| container_title | Chemical communications (Cambridge, England) |
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| creator | Martínez-Camarena, Álvaro Merino, Marian Sánchez-Sánchez, Ana Virginia Blasco, Salvador Llinares, José M Mullor, José L García-España, Enrique |
| description | A novel amino-nanozyme, based on boehmite nanoparticles (BNPs) functionalised with a tetra-azapyridinophane (
L1
), has been designed to undermine some of the key issues underlying Huntington disease.
L1
forms Cu
2+
complexes with a striking SOD activity, while when grafted to the BNPs displays mitoROS scavenging properties and ability to disaggregate mutant huntingtin deposits in cells.
Antioxidant amino-nanozymes shown both a prominent antioxidant activity and a striking capacity to remove mutant huntingtin aggregates. |
| doi_str_mv | 10.1039/d2cc01257j |
| format | Article |
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L1
), has been designed to undermine some of the key issues underlying Huntington disease.
L1
forms Cu
2+
complexes with a striking SOD activity, while when grafted to the BNPs displays mitoROS scavenging properties and ability to disaggregate mutant huntingtin deposits in cells.
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L1
), has been designed to undermine some of the key issues underlying Huntington disease.
L1
forms Cu
2+
complexes with a striking SOD activity, while when grafted to the BNPs displays mitoROS scavenging properties and ability to disaggregate mutant huntingtin deposits in cells.
Antioxidant amino-nanozymes shown both a prominent antioxidant activity and a striking capacity to remove mutant huntingtin aggregates.</description><subject>Aluminum Hydroxide</subject><subject>Aluminum Oxide</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Boehmite</subject><subject>Humans</subject><subject>Huntington Disease</subject><subject>Huntingtons disease</subject><subject>Inclusion Bodies</subject><subject>Nanoparticles</subject><subject>Scavenging</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0U1LwzAYB_AgipvTi3el4EERqnlpXnoc9WXKwIuCnkqbpDOjTWbTgvPTm7k5wVyehPzy8PAPAMcIXiFI0muFpYQIUz7fAUNEWBLTRLzurvY0jTlJ6AAceD-HYSEq9sGAUMKJgOkQvI1tVNjOuE-jQo1Kp98b0-moaIx1sS2s-1o24VjWOupcpIwvZrNWz4pgJn14aWeds-c-MlbWvTfOhh7KaH8I9qqi9vpoU0fg5e72OZvE06f7h2w8jSVmvIsrzlhFBK0o00qWiPKSJ1ohBbUsJSNEEc0EowRWVCRcQIhLLDSjaVkxLhgZgYt130XrPnrtu7wxXuq6Lqx2vc8xS1iaEERgoGf_6Nz1rQ3TBUVxCIcxHNTlWsnWed_qKl-0pinaZY5gvgo8v8FZ9hP4Y8Cnm5Z92Wi1pb8JB3CyBq2X29u_HyPfwIWEwg</recordid><startdate>20220419</startdate><enddate>20220419</enddate><creator>Martínez-Camarena, Álvaro</creator><creator>Merino, Marian</creator><creator>Sánchez-Sánchez, Ana Virginia</creator><creator>Blasco, Salvador</creator><creator>Llinares, José M</creator><creator>Mullor, José L</creator><creator>García-España, Enrique</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8142-8337</orcidid><orcidid>https://orcid.org/0000-0003-3763-4317</orcidid><orcidid>https://orcid.org/0000-0001-9910-6961</orcidid><orcidid>https://orcid.org/0000-0002-4601-6505</orcidid></search><sort><creationdate>20220419</creationdate><title>An antioxidant boehmite amino-nanozyme able to disaggregate Huntington's inclusion bodies</title><author>Martínez-Camarena, Álvaro ; Merino, Marian ; Sánchez-Sánchez, Ana Virginia ; Blasco, Salvador ; Llinares, José M ; Mullor, José L ; García-España, Enrique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c267t-f766f385f56edcb157b74ed1d0ecbc633d3e686530f58478002b28e659bf67863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aluminum Hydroxide</topic><topic>Aluminum Oxide</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Boehmite</topic><topic>Humans</topic><topic>Huntington Disease</topic><topic>Huntingtons disease</topic><topic>Inclusion Bodies</topic><topic>Nanoparticles</topic><topic>Scavenging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martínez-Camarena, Álvaro</creatorcontrib><creatorcontrib>Merino, Marian</creatorcontrib><creatorcontrib>Sánchez-Sánchez, Ana Virginia</creatorcontrib><creatorcontrib>Blasco, Salvador</creatorcontrib><creatorcontrib>Llinares, José M</creatorcontrib><creatorcontrib>Mullor, José L</creatorcontrib><creatorcontrib>García-España, Enrique</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martínez-Camarena, Álvaro</au><au>Merino, Marian</au><au>Sánchez-Sánchez, Ana Virginia</au><au>Blasco, Salvador</au><au>Llinares, José M</au><au>Mullor, José L</au><au>García-España, Enrique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An antioxidant boehmite amino-nanozyme able to disaggregate Huntington's inclusion bodies</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><addtitle>Chem Commun (Camb)</addtitle><date>2022-04-19</date><risdate>2022</risdate><volume>58</volume><issue>32</issue><spage>521</spage><epage>524</epage><pages>521-524</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>A novel amino-nanozyme, based on boehmite nanoparticles (BNPs) functionalised with a tetra-azapyridinophane (
L1
), has been designed to undermine some of the key issues underlying Huntington disease.
L1
forms Cu
2+
complexes with a striking SOD activity, while when grafted to the BNPs displays mitoROS scavenging properties and ability to disaggregate mutant huntingtin deposits in cells.
Antioxidant amino-nanozymes shown both a prominent antioxidant activity and a striking capacity to remove mutant huntingtin aggregates.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35373809</pmid><doi>10.1039/d2cc01257j</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-8142-8337</orcidid><orcidid>https://orcid.org/0000-0003-3763-4317</orcidid><orcidid>https://orcid.org/0000-0001-9910-6961</orcidid><orcidid>https://orcid.org/0000-0002-4601-6505</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1359-7345 |
| ispartof | Chemical communications (Cambridge, England), 2022-04, Vol.58 (32), p.521-524 |
| issn | 1359-7345 1364-548X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2646943130 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Aluminum Hydroxide Aluminum Oxide Antioxidants Antioxidants - pharmacology Boehmite Humans Huntington Disease Huntingtons disease Inclusion Bodies Nanoparticles Scavenging |
| title | An antioxidant boehmite amino-nanozyme able to disaggregate Huntington's inclusion bodies |
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